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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-157 Sentence denotes Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor.
T1 0-157 Sentence denotes Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor.
TextSentencer_T2 158-168 Sentence denotes OBJECTIVE:
T2 158-168 Sentence denotes OBJECTIVE:
TextSentencer_T3 169-471 Sentence denotes Preeclampsia has been proposed to be an antiangiogenic state that may be detected by the determination of the concentrations of the soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and placental growth factor (PlGF) in maternal blood even before the clinical development of the disease.
T3 169-471 Sentence denotes Preeclampsia has been proposed to be an antiangiogenic state that may be detected by the determination of the concentrations of the soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) and placental growth factor (PlGF) in maternal blood even before the clinical development of the disease.
TextSentencer_T4 472-752 Sentence denotes The purpose of this study was to determine the role of the combined use of uterine artery Doppler velocimetry (UADV) and maternal plasma PlGF and sVEGFR-1 concentrations in the second trimester for the identification of patients at risk for severe and/or early onset preeclampsia.
T4 472-752 Sentence denotes The purpose of this study was to determine the role of the combined use of uterine artery Doppler velocimetry (UADV) and maternal plasma PlGF and sVEGFR-1 concentrations in the second trimester for the identification of patients at risk for severe and/or early onset preeclampsia.
TextSentencer_T5 753-766 Sentence denotes STUDY DESIGN:
T5 753-766 Sentence denotes STUDY DESIGN:
TextSentencer_T6 767-927 Sentence denotes A prospective cohort study was designed to examine the relationship between abnormal UADV and plasma concentrations of PlGF and sVEGFR-1 in 3348 pregnant women.
T6 767-927 Sentence denotes A prospective cohort study was designed to examine the relationship between abnormal UADV and plasma concentrations of PlGF and sVEGFR-1 in 3348 pregnant women.
TextSentencer_T7 928-1032 Sentence denotes Plasma samples were obtained between 22 and 26 weeks of gestation at the time of ultrasound examination.
T7 928-1032 Sentence denotes Plasma samples were obtained between 22 and 26 weeks of gestation at the time of ultrasound examination.
TextSentencer_T8 1033-1193 Sentence denotes Abnormal UADV was defined as the presence of bilateral uterine artery notches and/or a mean pulsatility index above the 95th percentile for the gestational age.
T8 1033-1193 Sentence denotes Abnormal UADV was defined as the presence of bilateral uterine artery notches and/or a mean pulsatility index above the 95th percentile for the gestational age.
TextSentencer_T9 1194-1311 Sentence denotes Maternal plasma PlGF and sVEGFR-1 concentrations were determined with the use of sensitive and specific immunoassays.
T9 1194-1311 Sentence denotes Maternal plasma PlGF and sVEGFR-1 concentrations were determined with the use of sensitive and specific immunoassays.
TextSentencer_T10 1312-1438 Sentence denotes The primary outcome was the development of early onset preeclampsia (< or = 34 weeks of gestation) and/or severe preeclampsia.
T10 1312-1438 Sentence denotes The primary outcome was the development of early onset preeclampsia (< or = 34 weeks of gestation) and/or severe preeclampsia.
TextSentencer_T11 1439-1679 Sentence denotes Secondary outcomes included preeclampsia, the delivery of a small for gestational age (SGA) neonate without preeclampsia, spontaneous preterm birth at < or = 32 and < or = 35 weeks of gestation, and a composite of severe neonatal morbidity.
T11 1439-1679 Sentence denotes Secondary outcomes included preeclampsia, the delivery of a small for gestational age (SGA) neonate without preeclampsia, spontaneous preterm birth at < or = 32 and < or = 35 weeks of gestation, and a composite of severe neonatal morbidity.
TextSentencer_T12 1680-1830 Sentence denotes Contingency tables, chi-square test, receiver operating characteristic curve, and multivariate logistic regression were used for statistical analyses.
T12 1680-1830 Sentence denotes Contingency tables, chi-square test, receiver operating characteristic curve, and multivariate logistic regression were used for statistical analyses.
TextSentencer_T13 1831-1887 Sentence denotes A probability value of < .05 was considered significant.
T13 1831-1887 Sentence denotes A probability value of < .05 was considered significant.
TextSentencer_T14 1888-2054 Sentence denotes RESULTS: (1) The prevalence of preeclampsia, severe preeclampsia, and early onset preeclampsia were 3.4% (113/3296), 1.0% (33/3296), and 0.8% (25/3208), respectively.
T14 1888-2054 Sentence denotes RESULTS: (1) The prevalence of preeclampsia, severe preeclampsia, and early onset preeclampsia were 3.4% (113/3296), 1.0% (33/3296), and 0.8% (25/3208), respectively.
TextSentencer_T15 2055-3267 Sentence denotes UADV was performed in 95.4% (3146/3296) and maternal plasma PlGF concentrations were determined in 93.5% (3081/3296) of the study population. (2) Abnormal UADV and a maternal plasma PlGF of < 280 pg/mL were independent risk factors for the occurrence of preeclampsia, severe preeclampsia, early onset preeclampsia, and SGA without preeclampsia. (3) Among patients with abnormal UADV, maternal plasma PlGF concentration contributed significantly in the identification of patients destined to develop early onset preeclampsia (area under the curve, 0.80; P < .001) and severe preeclampsia (area under the curve, 0.77; P < .001). (4) In contrast, maternal plasma sVEGFR-1 concentration was of limited use in the prediction of early onset and/or severe preeclampsia. (5) The combination of abnormal UADV and maternal plasma PlGF of < 280 pg/mL was associated with an odds ratio (OR) of 43.8 (95% CI, 18.48-103.89) for the development of early onset preeclampsia, an OR of 37.4 (95% CI, 17.64-79.07) for the development of severe preeclampsia, an OR of 8.6 (95% CI, 5.35-13.74) for the development of preeclampsia, and an OR of 2.7 (95% CI, 1.73-4.26) for the delivery of a SGA neonate in the absence of preeclampsia.
T15 2055-3267 Sentence denotes UADV was performed in 95.4% (3146/3296) and maternal plasma PlGF concentrations were determined in 93.5% (3081/3296) of the study population. (2) Abnormal UADV and a maternal plasma PlGF of < 280 pg/mL were independent risk factors for the occurrence of preeclampsia, severe preeclampsia, early onset preeclampsia, and SGA without preeclampsia. (3) Among patients with abnormal UADV, maternal plasma PlGF concentration contributed significantly in the identification of patients destined to develop early onset preeclampsia (area under the curve, 0.80; P < .001) and severe preeclampsia (area under the curve, 0.77; P < .001). (4) In contrast, maternal plasma sVEGFR-1 concentration was of limited use in the prediction of early onset and/or severe preeclampsia. (5) The combination of abnormal UADV and maternal plasma PlGF of < 280 pg/mL was associated with an odds ratio (OR) of 43.8 (95% CI, 18.48-103.89) for the development of early onset preeclampsia, an OR of 37.4 (95% CI, 17.64-79.07) for the development of severe preeclampsia, an OR of 8.6 (95% CI, 5.35-13.74) for the development of preeclampsia, and an OR of 2.7 (95% CI, 1.73-4.26) for the delivery of a SGA neonate in the absence of preeclampsia.
TextSentencer_T16 3268-3279 Sentence denotes CONCLUSION:
T16 3268-3279 Sentence denotes CONCLUSION:
TextSentencer_T17 3280-3507 Sentence denotes The combination of abnormal UADV and maternal plasma PlGF concentration of < 280 pg/mL in the second trimester is associated with a high risk for preeclampsia and early onset and/or severe preeclampsia in a low-risk population.
T17 3280-3507 Sentence denotes The combination of abnormal UADV and maternal plasma PlGF concentration of < 280 pg/mL in the second trimester is associated with a high risk for preeclampsia and early onset and/or severe preeclampsia in a low-risk population.
TextSentencer_T18 3508-3679 Sentence denotes Among those with abnormal UADV, a maternal plasma concentration of PlGF of < 280 pg/mL identifies most patients who will experience early onset and/or severe preeclampsia.
T18 3508-3679 Sentence denotes Among those with abnormal UADV, a maternal plasma concentration of PlGF of < 280 pg/mL identifies most patients who will experience early onset and/or severe preeclampsia.