| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-178 |
Sentence |
denotes |
Human gliosarcoma-associated ganglioside composition is complex and distinctive as evidenced by high-performance mass spectrometric determination and structural characterization. |
| T1 |
0-178 |
Sentence |
denotes |
Human gliosarcoma-associated ganglioside composition is complex and distinctive as evidenced by high-performance mass spectrometric determination and structural characterization. |
| T1 |
0-178 |
Sentence |
denotes |
Human gliosarcoma-associated ganglioside composition is complex and distinctive as evidenced by high-performance mass spectrometric determination and structural characterization. |
| TextSentencer_T2 |
179-326 |
Sentence |
denotes |
Gangliosides (GGs), involved in malignant alteration and tumor progression/invasiveness, are considered as tumor biomarkers or therapeutic targets. |
| T2 |
179-326 |
Sentence |
denotes |
Gangliosides (GGs), involved in malignant alteration and tumor progression/invasiveness, are considered as tumor biomarkers or therapeutic targets. |
| T2 |
179-326 |
Sentence |
denotes |
Gangliosides (GGs), involved in malignant alteration and tumor progression/invasiveness, are considered as tumor biomarkers or therapeutic targets. |
| TextSentencer_T3 |
327-727 |
Sentence |
denotes |
Here, we describe the first systematic GG composition characterization in human gliosarcoma versus normal brain tissue using our recently developed mass spectrometry (MS) methods, based on nano-electrospray (nano-ESI), Fourier-transform ion cyclotron resonance (FT-ICR), and chip nano-ESI quadrupole time-of-flight (QTOF), complemented by thin-layer chromatographic (TLC) analysis and quantification. |
| T3 |
327-727 |
Sentence |
denotes |
Here, we describe the first systematic GG composition characterization in human gliosarcoma versus normal brain tissue using our recently developed mass spectrometry (MS) methods, based on nano-electrospray (nano-ESI), Fourier-transform ion cyclotron resonance (FT-ICR), and chip nano-ESI quadrupole time-of-flight (QTOF), complemented by thin-layer chromatographic (TLC) analysis and quantification. |
| T3 |
327-727 |
Sentence |
denotes |
Here, we describe the first systematic GG composition characterization in human gliosarcoma versus normal brain tissue using our recently developed mass spectrometry (MS) methods, based on nano-electrospray (nano-ESI), Fourier-transform ion cyclotron resonance (FT-ICR), and chip nano-ESI quadrupole time-of-flight (QTOF), complemented by thin-layer chromatographic (TLC) analysis and quantification. |
| TextSentencer_T4 |
728-867 |
Sentence |
denotes |
Combined MS enabled detection and structural assignment of 73 distinct GG species: many more than reported so far for investigated gliomas. |
| T4 |
728-867 |
Sentence |
denotes |
Combined MS enabled detection and structural assignment of 73 distinct GG species: many more than reported so far for investigated gliomas. |
| T4 |
728-867 |
Sentence |
denotes |
Combined MS enabled detection and structural assignment of 73 distinct GG species: many more than reported so far for investigated gliomas. |
| TextSentencer_T5 |
868-1126 |
Sentence |
denotes |
Apart from the 7.4-times lower total GG content, gliosarcoma contained all major brain-associated species, however, in very altered proportions, exhibiting a highly distinctive pattern: GD3 (48.9%)>GD1a/nLD1>GD2/GT3>GM3>GT1b>GM2>GM1a/GM1b/nLM1>LM1>GD1b>GQ1b. |
| T5 |
868-1126 |
Sentence |
denotes |
Apart from the 7.4-times lower total GG content, gliosarcoma contained all major brain-associated species, however, in very altered proportions, exhibiting a highly distinctive pattern: GD3 (48.9%)>GD1a/nLD1>GD2/GT3>GM3>GT1b>GM2>GM1a/GM1b/nLM1>LM1>GD1b>GQ1b. |
| T5 |
868-1126 |
Sentence |
denotes |
Apart from the 7.4-times lower total GG content, gliosarcoma contained all major brain-associated species, however, in very altered proportions, exhibiting a highly distinctive pattern: GD3 (48.9%)>GD1a/nLD1>GD2/GT3>GM3>GT1b>GM2>GM1a/GM1b/nLM1>LM1>GD1b>GQ1b. |
| TextSentencer_T6 |
1127-1324 |
Sentence |
denotes |
MS also revealed abundant O-Ac-GD3; its sequencing provided structural evidence to postulate a novel O-Ac-GD3 isomer O-acetylated at the inner Neu5Ac-residue, previously not structurally confirmed. |
| T6 |
1127-1324 |
Sentence |
denotes |
MS also revealed abundant O-Ac-GD3; its sequencing provided structural evidence to postulate a novel O-Ac-GD3 isomer O-acetylated at the inner Neu5Ac-residue, previously not structurally confirmed. |
| T6 |
1127-1324 |
Sentence |
denotes |
MS also revealed abundant O-Ac-GD3; its sequencing provided structural evidence to postulate a novel O-Ac-GD3 isomer O-acetylated at the inner Neu5Ac-residue, previously not structurally confirmed. |
| TextSentencer_T7 |
1325-1558 |
Sentence |
denotes |
The high sensitivity and mass accuracy permitted the assignment of unusual minor species: GM4, Hex-HexNAc-nLM1, Gal-GD1, Fuc-GT1, GalNAc-GT1, O-Ac-GM3, di- O-Ac-GD3O-Ac-GD3, and O-Ac-GT3, not previously reported as glioma-associated. |
| T7 |
1325-1558 |
Sentence |
denotes |
The high sensitivity and mass accuracy permitted the assignment of unusual minor species: GM4, Hex-HexNAc-nLM1, Gal-GD1, Fuc-GT1, GalNAc-GT1, O-Ac-GM3, di- O-Ac-GD3O-Ac-GD3, and O-Ac-GT3, not previously reported as glioma-associated. |
| T7 |
1325-1558 |
Sentence |
denotes |
The high sensitivity and mass accuracy permitted the assignment of unusual minor species: GM4, Hex-HexNAc-nLM1, Gal-GD1, Fuc-GT1, GalNAc-GT1, O-Ac-GM3, di- O-Ac-GD3O-Ac-GD3, and O-Ac-GT3, not previously reported as glioma-associated. |
| TextSentencer_T8 |
1559-1669 |
Sentence |
denotes |
The gliosarcoma-expressed GA2 might represent a marker distinguishing astrocytic from oligodendroglial tumors. |
| T8 |
1559-1669 |
Sentence |
denotes |
The gliosarcoma-expressed GA2 might represent a marker distinguishing astrocytic from oligodendroglial tumors. |
| T8 |
1559-1669 |
Sentence |
denotes |
The gliosarcoma-expressed GA2 might represent a marker distinguishing astrocytic from oligodendroglial tumors. |
| TextSentencer_T9 |
1670-1990 |
Sentence |
denotes |
This is, to our knowledge, so far the most complete GG composition characterization of certain glioma, which demonstrates that our MS-based approach could provide essential structural information relevant to glycosphingolipid role(s) in brain tumor biology, differential diagnosis/prognosis and novel treatment concepts. |
| T9 |
1670-1990 |
Sentence |
denotes |
This is, to our knowledge, so far the most complete GG composition characterization of certain glioma, which demonstrates that our MS-based approach could provide essential structural information relevant to glycosphingolipid role(s) in brain tumor biology, differential diagnosis/prognosis and novel treatment concepts. |
| T9 |
1670-1990 |
Sentence |
denotes |
This is, to our knowledge, so far the most complete GG composition characterization of certain glioma, which demonstrates that our MS-based approach could provide essential structural information relevant to glycosphingolipid role(s) in brain tumor biology, differential diagnosis/prognosis and novel treatment concepts. |