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PubMed:17251309 JSONTXT 53 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-116 Sentence denotes Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease.
T1 0-116 Sentence denotes Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease.
T1 0-116 Sentence denotes Effect of mannose chain length on targeting of glucocerebrosidase for enzyme replacement therapy of Gaucher disease.
TextSentencer_T2 117-237 Sentence denotes Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease.
T2 117-237 Sentence denotes Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease.
T2 117-237 Sentence denotes Recombinant human glucocerebrosidase (imiglucerase, Cerezyme) is used in enzyme replacement therapy for Gaucher disease.
TextSentencer_T3 238-450 Sentence denotes Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages.
T3 238-450 Sentence denotes Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages.
T3 238-450 Sentence denotes Complex oligosaccharides present on Chinese hamster ovary cell-expressed glucocerebrosidase (GCase) are enzymatically remodeled into a mannose core, facilitating mannose receptor-mediated uptake into macrophages.
TextSentencer_T4 451-627 Sentence denotes Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages.
T4 451-627 Sentence denotes Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages.
T4 451-627 Sentence denotes Alternative expression systems could be used to produce GCase containing larger oligomannose structures, offering the possibility of an improvement in targeting to macrophages.
TextSentencer_T5 628-737 Sentence denotes A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling.
T5 628-737 Sentence denotes A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling.
T5 628-737 Sentence denotes A secondary advantage of these expression systems would be to eliminate the need for carbohydrate remodeling.
TextSentencer_T6 738-861 Sentence denotes Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9.
T6 738-861 Sentence denotes Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9.
T6 738-861 Sentence denotes Here, multiple expression systems were used to produce GCase containing primarily terminal oligomannose, from Man2 to Man9.
TextSentencer_T7 862-1065 Sentence denotes GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life.
T7 862-1065 Sentence denotes GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life.
T7 862-1065 Sentence denotes GCase from these multiple expression systems was compared to Cerezyme with respect to affinity for mannose receptor and serum mannose-binding lectin (MBL), macrophage uptake, and intracellular half-life.
TextSentencer_T8 1066-1210 Sentence denotes In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null).
T8 1066-1210 Sentence denotes In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null).
T8 1066-1210 Sentence denotes In vivo studies comparing clearance and targeting of Cerezyme and the Man9 form of GCase were carried out in a Gaucher mouse model (D409V/null).
TextSentencer_T9 1211-1314 Sentence denotes Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase.
T9 1211-1314 Sentence denotes Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase.
T9 1211-1314 Sentence denotes Mannose receptor binding, macrophage uptake, and in vivo targeting were similar for all forms of GCase.
TextSentencer_T10 1315-1477 Sentence denotes Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior.
T10 1315-1477 Sentence denotes Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior.
T10 1315-1477 Sentence denotes Increased MBL binding was observed for all forms of GCase having larger mannose structures than those of Cerezyme, which could influence pharmacokinetic behavior.
TextSentencer_T11 1478-1743 Sentence denotes These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues.
T11 1478-1743 Sentence denotes These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues.
T11 1478-1743 Sentence denotes These studies demonstrate that although alternative cell expression systems are effective for producing oligomannose-terminated glucocerebrosidase, there is no biochemical or pharmacological advantage in producing GCase with an increased number of mannose residues.
TextSentencer_T12 1744-2004 Sentence denotes The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans.
T12 1744-2004 Sentence denotes The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans.
T12 1744-2004 Sentence denotes The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans.