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PubMed:17202136 JSONTXT 42 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-146 Sentence denotes A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity.
T1 0-146 Sentence denotes A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity.
TextSentencer_T2 147-177 Sentence denotes Zinc is an essential nutrient.
T2 147-177 Sentence denotes Zinc is an essential nutrient.
TextSentencer_T3 178-299 Sentence denotes Genetic evidence for this nutritional requirement in humans is the zinc deficiency disease, acrodermatitis enteropathica.
T3 178-299 Sentence denotes Genetic evidence for this nutritional requirement in humans is the zinc deficiency disease, acrodermatitis enteropathica.
TextSentencer_T4 300-434 Sentence denotes This disorder is caused by mutations in hZIP4 (SLC39A4), a zinc importer required for zinc uptake in enterocytes and other cell types.
T4 300-434 Sentence denotes This disorder is caused by mutations in hZIP4 (SLC39A4), a zinc importer required for zinc uptake in enterocytes and other cell types.
TextSentencer_T5 435-615 Sentence denotes Studies in mice have demonstrated that levels of the mZIP4 mRNA are reduced by elevated dietary zinc, resulting in a decreased abundance of the ZIP4 protein at the plasma membrane.
T5 435-615 Sentence denotes Studies in mice have demonstrated that levels of the mZIP4 mRNA are reduced by elevated dietary zinc, resulting in a decreased abundance of the ZIP4 protein at the plasma membrane.
TextSentencer_T6 616-809 Sentence denotes Moreover, studies in cultured cells have demonstrated that low micromolar concentrations of zinc stimulate the endocytosis of the mZIP4 protein resulting in a reduction in cellular zinc uptake.
T6 616-809 Sentence denotes Moreover, studies in cultured cells have demonstrated that low micromolar concentrations of zinc stimulate the endocytosis of the mZIP4 protein resulting in a reduction in cellular zinc uptake.
TextSentencer_T7 810-973 Sentence denotes In this study, we demonstrate an additional level of hZIP4 regulation involving ubiquitination and degradation of this transporter in elevated zinc concentrations.
T7 810-973 Sentence denotes In this study, we demonstrate an additional level of hZIP4 regulation involving ubiquitination and degradation of this transporter in elevated zinc concentrations.
TextSentencer_T8 974-1141 Sentence denotes Mutational analysis identified a cytoplasmic histidine-rich domain that was essential for ubiquitin-dependent degradation of ZIP4 and protection against zinc toxicity.
T8 974-1141 Sentence denotes Mutational analysis identified a cytoplasmic histidine-rich domain that was essential for ubiquitin-dependent degradation of ZIP4 and protection against zinc toxicity.
TextSentencer_T9 1142-1207 Sentence denotes However, this motif was dispensable for zinc-induced endocytosis.
T9 1142-1207 Sentence denotes However, this motif was dispensable for zinc-induced endocytosis.
TextSentencer_T10 1208-1464 Sentence denotes These findings indicate that ubiquitin-mediated degradation of the ZIP4 protein is critical for regulating zinc homeostasis in response to the upper tier of physiological zinc concentrations, via a process that is distinct from zinc-stimulated endocytosis.
T10 1208-1464 Sentence denotes These findings indicate that ubiquitin-mediated degradation of the ZIP4 protein is critical for regulating zinc homeostasis in response to the upper tier of physiological zinc concentrations, via a process that is distinct from zinc-stimulated endocytosis.