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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-168 Sentence denotes Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
T1 0-168 Sentence denotes Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
TextSentencer_T2 169-235 Sentence denotes Mechanisms of invasion in thyroid cancer remain poorly understood.
T2 169-235 Sentence denotes Mechanisms of invasion in thyroid cancer remain poorly understood.
TextSentencer_T3 236-431 Sentence denotes We hypothesized that signaling via the epidermal growth factor receptor (EGFR) stimulates thyroid cancer cell invasion by altering the expression and cleavage of matrix metalloproteinases (MMPs).
T3 236-431 Sentence denotes We hypothesized that signaling via the epidermal growth factor receptor (EGFR) stimulates thyroid cancer cell invasion by altering the expression and cleavage of matrix metalloproteinases (MMPs).
TextSentencer_T4 432-585 Sentence denotes Papillary and follicular carcinoma cell lines were treated with EGF, the EGFR tyrosine kinase inhibitor AG1478, and the MMP inhibitors GM-6001 and Col-3.
T4 432-585 Sentence denotes Papillary and follicular carcinoma cell lines were treated with EGF, the EGFR tyrosine kinase inhibitor AG1478, and the MMP inhibitors GM-6001 and Col-3.
TextSentencer_T5 586-625 Sentence denotes Flow cytometry was used to detect EGFR.
T5 586-625 Sentence denotes Flow cytometry was used to detect EGFR.
TextSentencer_T6 626-802 Sentence denotes In vitro invasion assays, gelatin zymography, and quantitative reverse transcription-PCR were used to assess the changes in invasive behavior and MMP expression and activation.
T6 626-802 Sentence denotes In vitro invasion assays, gelatin zymography, and quantitative reverse transcription-PCR were used to assess the changes in invasive behavior and MMP expression and activation.
TextSentencer_T7 803-860 Sentence denotes All cell lines were found to overexpress functional EGFR.
T7 803-860 Sentence denotes All cell lines were found to overexpress functional EGFR.
TextSentencer_T8 861-1073 Sentence denotes EGF stimulated invasion by thyroid cancer cells up to sevenfold (P<0.0001), a process that was antagonized completely by AG1478 and Col-3, partially by GM-6001, but not by the serine protease inhibitor aprotinin.
T8 861-1073 Sentence denotes EGF stimulated invasion by thyroid cancer cells up to sevenfold (P<0.0001), a process that was antagonized completely by AG1478 and Col-3, partially by GM-6001, but not by the serine protease inhibitor aprotinin.
TextSentencer_T9 1074-1205 Sentence denotes EGF upregulated expression of MMP-9 (2.64- to 8.89-fold, P<0.0001) and membrane type-1 MMP (MT1-MMP, 1.97- to 2.67-fold, P<0.0001).
T9 1074-1205 Sentence denotes EGF upregulated expression of MMP-9 (2.64- to 8.89-fold, P<0.0001) and membrane type-1 MMP (MT1-MMP, 1.97- to 2.67-fold, P<0.0001).
TextSentencer_T10 1206-1274 Sentence denotes This effect was blocked completely by AG1478 and partially by Col-3.
T10 1206-1274 Sentence denotes This effect was blocked completely by AG1478 and partially by Col-3.
TextSentencer_T11 1275-1329 Sentence denotes The activation of MMP-2 paralleled MT1-MMP expression.
T11 1275-1329 Sentence denotes The activation of MMP-2 paralleled MT1-MMP expression.
TextSentencer_T12 1330-1456 Sentence denotes We demonstrate that MMPs are critical effectors of invasion in the papillary and follicular thyroid cancer cell lines studied.
T12 1330-1456 Sentence denotes We demonstrate that MMPs are critical effectors of invasion in the papillary and follicular thyroid cancer cell lines studied.
TextSentencer_T13 1457-1581 Sentence denotes Invasion is regulated by signaling through EGFR, an effect mediated by augmentation of gelatinase expression and activation.
T13 1457-1581 Sentence denotes Invasion is regulated by signaling through EGFR, an effect mediated by augmentation of gelatinase expression and activation.
TextSentencer_T14 1582-1715 Sentence denotes MMP inhibitors and growth factor antagonists may be effective tumoristatic agents for the treatment of aggressive thyroid carcinomas.
T14 1582-1715 Sentence denotes MMP inhibitors and growth factor antagonists may be effective tumoristatic agents for the treatment of aggressive thyroid carcinomas.