| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-130 |
Sentence |
denotes |
The plasma cell membrane glycoprotein, PC-1, is a threonine-specific protein kinase stimulated by acidic fibroblast growth factor. |
| T1 |
0-130 |
Sentence |
denotes |
The plasma cell membrane glycoprotein, PC-1, is a threonine-specific protein kinase stimulated by acidic fibroblast growth factor. |
| T2 |
131-343 |
Sentence |
denotes |
A 32P-labeled protein that co-purified with acidic fibroblast growth factor (aFGF) receptor from bovine liver proved to be a distinct membrane protein, which itself has kinase activity that is stimulated by aFGF. |
| T2 |
131-343 |
Sentence |
denotes |
A 32P-labeled protein that co-purified with acidic fibroblast growth factor (aFGF) receptor from bovine liver proved to be a distinct membrane protein, which itself has kinase activity that is stimulated by aFGF. |
| T3 |
344-417 |
Sentence |
denotes |
The protein was designated MAFP for major aFGF-stimulated phosphoprotein. |
| T3 |
344-417 |
Sentence |
denotes |
The protein was designated MAFP for major aFGF-stimulated phosphoprotein. |
| T4 |
418-634 |
Sentence |
denotes |
MAFP was purified from bovine liver using immunoaffinity chromatography with monoclonal antibody to MAFP following Triton X-100 extraction of plasma membranes and wheat germ lectin-Sepharose 4B column chromatography. |
| T4 |
418-634 |
Sentence |
denotes |
MAFP was purified from bovine liver using immunoaffinity chromatography with monoclonal antibody to MAFP following Triton X-100 extraction of plasma membranes and wheat germ lectin-Sepharose 4B column chromatography. |
| T5 |
635-817 |
Sentence |
denotes |
The purified MAFP showed molecular masses of 130 kDa and 260 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing and nonreducing conditions, respectively. |
| T5 |
635-817 |
Sentence |
denotes |
The purified MAFP showed molecular masses of 130 kDa and 260 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing and nonreducing conditions, respectively. |
| T6 |
818-989 |
Sentence |
denotes |
Purified MAFP elicited aFGF-stimulated Thr-specific autophosphorylation activity and phosphorylation activity toward protein substrates (myelin basic protein and histone). |
| T6 |
818-989 |
Sentence |
denotes |
Purified MAFP elicited aFGF-stimulated Thr-specific autophosphorylation activity and phosphorylation activity toward protein substrates (myelin basic protein and histone). |
| T7 |
990-1294 |
Sentence |
denotes |
Amino acid sequence analyses of 16 peptide fragments of MAFP, produced by endoproteinase Lys-C digestion followed by reduction and S-pyridylethylation, showed approximately 80-100% homology with the cDNA-deduced amino acid sequences of human and mouse plasma cell membrane glycoprotein, PC-1 (Buckley, M. |
| T7 |
990-1294 |
Sentence |
denotes |
Amino acid sequence analyses of 16 peptide fragments of MAFP, produced by endoproteinase Lys-C digestion followed by reduction and S-pyridylethylation, showed approximately 80-100% homology with the cDNA-deduced amino acid sequences of human and mouse plasma cell membrane glycoprotein, PC-1 (Buckley, M. |
| T8 |
1295-1311 |
Sentence |
denotes |
F., Loveland, K. |
| T8 |
1295-1311 |
Sentence |
denotes |
F., Loveland, K. |
| T9 |
1312-1329 |
Sentence |
denotes |
A., McKinstry, W. |
| T9 |
1312-1329 |
Sentence |
denotes |
A., McKinstry, W. |
| T10 |
1330-1344 |
Sentence |
denotes |
J., Garson, O. |
| T10 |
1330-1344 |
Sentence |
denotes |
J., Garson, O. |
| T11 |
1345-1363 |
Sentence |
denotes |
M., and Goding, J. |
| T11 |
1345-1363 |
Sentence |
denotes |
M., and Goding, J. |
| T12 |
1364-1376 |
Sentence |
denotes |
W. (1990) J. |
| T12 |
1364-1376 |
Sentence |
denotes |
W. (1990) J. |
| T13 |
1377-1382 |
Sentence |
denotes |
Biol. |
| T13 |
1377-1382 |
Sentence |
denotes |
Biol. |
| T14 |
1383-1388 |
Sentence |
denotes |
Chem. |
| T14 |
1383-1388 |
Sentence |
denotes |
Chem. |
| T15 |
1389-1459 |
Sentence |
denotes |
265, 17506-17511), suggesting that MAFP is the bovine version of PC-1. |
| T15 |
1389-1459 |
Sentence |
denotes |
265, 17506-17511), suggesting that MAFP is the bovine version of PC-1. |
| T16 |
1460-1588 |
Sentence |
denotes |
The amino acid sequences of bovine MAFP, human and mouse PC-1 reveal a putative ATP binding site in their extracellular domains. |
| T16 |
1460-1588 |
Sentence |
denotes |
The amino acid sequences of bovine MAFP, human and mouse PC-1 reveal a putative ATP binding site in their extracellular domains. |
| T17 |
1589-1652 |
Sentence |
denotes |
These results suggest that MAFP(PC-1) is an ectoprotein kinase. |
| T17 |
1589-1652 |
Sentence |
denotes |
These results suggest that MAFP(PC-1) is an ectoprotein kinase. |
| T18 |
1653-1773 |
Sentence |
denotes |
In addition to the kinase activity, MAFP(PC-1) was also found to possess alkaline nucleotide phosphodiesterase activity. |
| T18 |
1653-1773 |
Sentence |
denotes |
In addition to the kinase activity, MAFP(PC-1) was also found to possess alkaline nucleotide phosphodiesterase activity. |
| T19 |
1774-2031 |
Sentence |
denotes |
It is now clear that several of the unique properties previously attributed to the aFGF receptor kinase are actually properties of this novel Thr-specific ectoprotein kinase, which co-purifies with the aFGF receptor and is responsive to stimulation by aFGF. |
| T19 |
1774-2031 |
Sentence |
denotes |
It is now clear that several of the unique properties previously attributed to the aFGF receptor kinase are actually properties of this novel Thr-specific ectoprotein kinase, which co-purifies with the aFGF receptor and is responsive to stimulation by aFGF. |