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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-195 Sentence denotes Thyroid-stimulating hormone receptor messenger ribonucleic acid measurement in blood as a marker for circulating thyroid cancer cells and its role in the preoperative diagnosis of thyroid cancer.
T1 0-195 Sentence denotes Thyroid-stimulating hormone receptor messenger ribonucleic acid measurement in blood as a marker for circulating thyroid cancer cells and its role in the preoperative diagnosis of thyroid cancer.
TextSentencer_T2 196-204 Sentence denotes CONTEXT:
T2 196-204 Sentence denotes CONTEXT:
TextSentencer_T3 205-380 Sentence denotes Thyroid cancer cells express TSH receptor (TSHR) mRNA, and its measurement in the circulation may be useful in the diagnosis/management of differentiated thyroid cancer (DTC).
T3 205-380 Sentence denotes Thyroid cancer cells express TSH receptor (TSHR) mRNA, and its measurement in the circulation may be useful in the diagnosis/management of differentiated thyroid cancer (DTC).
TextSentencer_T4 381-391 Sentence denotes OBJECTIVE:
T4 381-391 Sentence denotes OBJECTIVE:
TextSentencer_T5 392-533 Sentence denotes Our objective was to assess the diagnostic value of circulating TSHR mRNA for preoperative detection of DTC in patients with thyroid nodules.
T5 392-533 Sentence denotes Our objective was to assess the diagnostic value of circulating TSHR mRNA for preoperative detection of DTC in patients with thyroid nodules.
TextSentencer_T6 534-543 Sentence denotes PATIENTS:
T6 534-543 Sentence denotes PATIENTS:
TextSentencer_T7 544-599 Sentence denotes We measured TSHR mRNA levels by RT-PCR in 258 subjects:
T7 544-599 Sentence denotes We measured TSHR mRNA levels by RT-PCR in 258 subjects:
TextSentencer_T8 600-761 Sentence denotes 51 healthy subjects and 207 patients (thyroid nodules, n = 180; recurrent thyroid cancer, n = 27) with fine-needle aspirations (FNA) and/or thyroid/neck surgery.
T8 600-761 Sentence denotes 51 healthy subjects and 207 patients (thyroid nodules, n = 180; recurrent thyroid cancer, n = 27) with fine-needle aspirations (FNA) and/or thyroid/neck surgery.
TextSentencer_T9 762-826 Sentence denotes Eighty-nine patients also had d-1 postoperative levels assessed.
T9 762-826 Sentence denotes Eighty-nine patients also had d-1 postoperative levels assessed.
TextSentencer_T10 827-999 Sentence denotes OUTCOME MEASURES: TSHR mRNA levels were compared with FNA cytology for cancer detection preoperatively and serum thyroglobulin and/or whole-body 131I scans postoperatively.
T10 827-999 Sentence denotes OUTCOME MEASURES: TSHR mRNA levels were compared with FNA cytology for cancer detection preoperatively and serum thyroglobulin and/or whole-body 131I scans postoperatively.
TextSentencer_T11 1000-1008 Sentence denotes RESULTS:
T11 1000-1008 Sentence denotes RESULTS:
TextSentencer_T12 1009-1093 Sentence denotes Based on cytology/pathology, 88 patients had DTC and 119 had benign thyroid disease.
T12 1009-1093 Sentence denotes Based on cytology/pathology, 88 patients had DTC and 119 had benign thyroid disease.
TextSentencer_T13 1094-1196 Sentence denotes The TSHR mRNA levels in cancer patients were significantly higher than in benign disease (P < 0.0001).
T13 1094-1196 Sentence denotes The TSHR mRNA levels in cancer patients were significantly higher than in benign disease (P < 0.0001).
TextSentencer_T14 1197-1355 Sentence denotes At a cutoff value of 1.02 ng/microg total RNA, the TSHR mRNA correctly classified 78.7% of patients preoperatively (sensitivity = 72.0%; specificity = 82.5%).
T14 1197-1355 Sentence denotes At a cutoff value of 1.02 ng/microg total RNA, the TSHR mRNA correctly classified 78.7% of patients preoperatively (sensitivity = 72.0%; specificity = 82.5%).
TextSentencer_T15 1356-1501 Sentence denotes Of 131 patients with FNA and surgery, 51 were FNA positive (all cancer), 17 were FNA negative (15 benign, two cancer), and 63 were indeterminate.
T15 1356-1501 Sentence denotes Of 131 patients with FNA and surgery, 51 were FNA positive (all cancer), 17 were FNA negative (15 benign, two cancer), and 63 were indeterminate.
TextSentencer_T16 1502-1671 Sentence denotes TSHR mRNA correctly diagnosed DTC in 16 of 24 (67%) and benign disease in 29 of 39 (74%) patients with indeterminate FNA (combined sensitivity = 90%; specificity = 80%).
T16 1502-1671 Sentence denotes TSHR mRNA correctly diagnosed DTC in 16 of 24 (67%) and benign disease in 29 of 39 (74%) patients with indeterminate FNA (combined sensitivity = 90%; specificity = 80%).
TextSentencer_T17 1672-1858 Sentence denotes Combining TSHR mRNA and ultrasound features for follicular lesions correctly classified all follicular cancers and could have spared surgery in 31% of these patients with benign disease.
T17 1672-1858 Sentence denotes Combining TSHR mRNA and ultrasound features for follicular lesions correctly classified all follicular cancers and could have spared surgery in 31% of these patients with benign disease.
TextSentencer_T18 1859-2044 Sentence denotes TSHR mRNA has a short life in circulation, and normalized levels on postoperative d 1 correlated with disease-free status, whereas elevated levels predicted residual/metastatic disease.
T18 1859-2044 Sentence denotes TSHR mRNA has a short life in circulation, and normalized levels on postoperative d 1 correlated with disease-free status, whereas elevated levels predicted residual/metastatic disease.
TextSentencer_T19 2045-2273 Sentence denotes CONCLUSIONS: TSHR mRNA measured with FNA enhances the preoperative detection of cancer in patients with thyroid nodules, reducing unnecessary surgeries, and immediate postoperative levels can predict residual/metastatic disease.
T19 2045-2273 Sentence denotes CONCLUSIONS: TSHR mRNA measured with FNA enhances the preoperative detection of cancer in patients with thyroid nodules, reducing unnecessary surgeries, and immediate postoperative levels can predict residual/metastatic disease.