| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-128 |
Sentence |
denotes |
Multiplexed mass spectrometric immunoassay in biomarker research: a novel approach to the determination of a myocardial infarct. |
| T1 |
0-128 |
Sentence |
denotes |
Multiplexed mass spectrometric immunoassay in biomarker research: a novel approach to the determination of a myocardial infarct. |
| TextSentencer_T2 |
129-265 |
Sentence |
denotes |
Reported here is the development of a multiplexed mass spectrometric immunoassay (MSIA) for the detection of myocardial infarction (MI). |
| T2 |
129-265 |
Sentence |
denotes |
Reported here is the development of a multiplexed mass spectrometric immunoassay (MSIA) for the detection of myocardial infarction (MI). |
| TextSentencer_T3 |
266-453 |
Sentence |
denotes |
The assay is the product of a study that systematically progresses from biomarker discovery--to identification and verification--to assay design, data analysis, and statistical challenge. |
| T3 |
266-453 |
Sentence |
denotes |
The assay is the product of a study that systematically progresses from biomarker discovery--to identification and verification--to assay design, data analysis, and statistical challenge. |
| TextSentencer_T4 |
454-616 |
Sentence |
denotes |
During targeted population proteomics investigations, two novel biomarkers, serum amyloid A1alpha and S-sulfated transthyretin, were found to be responsive to MI. |
| T4 |
454-616 |
Sentence |
denotes |
During targeted population proteomics investigations, two novel biomarkers, serum amyloid A1alpha and S-sulfated transthyretin, were found to be responsive to MI. |
| TextSentencer_T5 |
617-741 |
Sentence |
denotes |
These putative markers were subsequently screened in larger cohorts of individuals to verify their responsiveness toward MI. |
| T5 |
617-741 |
Sentence |
denotes |
These putative markers were subsequently screened in larger cohorts of individuals to verify their responsiveness toward MI. |
| TextSentencer_T6 |
742-908 |
Sentence |
denotes |
Upon verification, a multiplexed assay was designed that was capable of simultaneously monitoring the new markers plus a previously established MI-marker (myoglobin). |
| T6 |
742-908 |
Sentence |
denotes |
Upon verification, a multiplexed assay was designed that was capable of simultaneously monitoring the new markers plus a previously established MI-marker (myoglobin). |
| TextSentencer_T7 |
909-1072 |
Sentence |
denotes |
The multiplexed MSIA was applied to two 96-sample sets comprised of 48-MI/48-healthy and 19-MI/77-healthy, which served as training and case cohorts, respectively. |
| T7 |
909-1072 |
Sentence |
denotes |
The multiplexed MSIA was applied to two 96-sample sets comprised of 48-MI/48-healthy and 19-MI/77-healthy, which served as training and case cohorts, respectively. |
| TextSentencer_T8 |
1073-1201 |
Sentence |
denotes |
Data evaluation using either preset reference levels or multivariate analysis exhibited sensitivities and specificities of >97%. |
| T8 |
1073-1201 |
Sentence |
denotes |
Data evaluation using either preset reference levels or multivariate analysis exhibited sensitivities and specificities of >97%. |
| TextSentencer_T9 |
1202-1376 |
Sentence |
denotes |
These findings illustrate the importance of using systematic approaches in clinical proteomics to discover biomarkers and produce high-performance assays relevant to disease. |
| T9 |
1202-1376 |
Sentence |
denotes |
These findings illustrate the importance of using systematic approaches in clinical proteomics to discover biomarkers and produce high-performance assays relevant to disease. |