| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-127 |
Sentence |
denotes |
Sustained activity of calcium release-activated calcium channels requires translocation of mitochondria to the plasma membrane. |
| T2 |
128-210 |
Sentence |
denotes |
A rise of the intracellular Ca(2+) concentration has multiple signaling functions. |
| T3 |
211-468 |
Sentence |
denotes |
Sustained Ca(2+) influx across plasma membrane through calcium release-activated calcium (CRAC) channels is required for T-cell development in the thymus, gene transcription, and proliferation and differentiation of naïve T-cells into armed effectors cells. |
| T4 |
469-575 |
Sentence |
denotes |
Intracellular Ca(2+) signals are shaped by mitochondria, which function as a highly dynamic Ca(2+) buffer. |
| T5 |
576-668 |
Sentence |
denotes |
However, the precise role of mitochondria for Ca(2+)-dependent T-cell activation is unknown. |
| T6 |
669-872 |
Sentence |
denotes |
Here we have shown that mitochondria are translocated to the plasma membrane as a consequence of Ca(2+) influx and that this directed movement is essential to sustain Ca(2+) influx through CRAC channels. |
| T7 |
873-1127 |
Sentence |
denotes |
The decreased distance between mitochondria and the plasma membrane enabled mitochondria to take up large amounts of inflowing Ca(2+) at the plasma membrane, thereby preventing Ca(2+)-dependent inactivation of CRAC channels and sustaining Ca(2+) signals. |
| T8 |
1128-1277 |
Sentence |
denotes |
Inhibition of kinesin-dependent mitochondrial movement along microtubules abolished mitochondrial translocation and reduced sustained Ca(2+) signals. |
| T9 |
1278-1426 |
Sentence |
denotes |
Our results show how a directed movement of mitochondria is used to control important cellular functions such as Ca(2+)-dependent T-cell activation. |
