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PubMed:17000699 JSONTXT 52 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-105 Sentence denotes Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy.
T1 0-105 Sentence denotes Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy.
T1 0-105 Sentence denotes Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy.
TextSentencer_T2 106-219 Sentence denotes MFECP1 is a mannosylated antibody-enzyme fusion protein used in antibody-directed enzyme prodrug therapy (ADEPT).
T2 106-219 Sentence denotes MFECP1 is a mannosylated antibody-enzyme fusion protein used in antibody-directed enzyme prodrug therapy (ADEPT).
T2 106-219 Sentence denotes MFECP1 is a mannosylated antibody-enzyme fusion protein used in antibody-directed enzyme prodrug therapy (ADEPT).
TextSentencer_T3 220-326 Sentence denotes The antibody selectively targets tumor cells and the targeted enzyme converts a prodrug into a toxic drug.
T3 220-326 Sentence denotes The antibody selectively targets tumor cells and the targeted enzyme converts a prodrug into a toxic drug.
T3 220-326 Sentence denotes The antibody selectively targets tumor cells and the targeted enzyme converts a prodrug into a toxic drug.
TextSentencer_T4 327-422 Sentence denotes MFECP1 is obtained from expression in the yeast Pichia pastoris and produced to clinical grade.
T4 327-422 Sentence denotes MFECP1 is obtained from expression in the yeast Pichia pastoris and produced to clinical grade.
T4 327-422 Sentence denotes MFECP1 is obtained from expression in the yeast Pichia pastoris and produced to clinical grade.
TextSentencer_T5 423-548 Sentence denotes The P. pastoris-derived mannosylation of the fusion protein aids rapid normal tissue clearance required for successful ADEPT.
T5 423-548 Sentence denotes The P. pastoris-derived mannosylation of the fusion protein aids rapid normal tissue clearance required for successful ADEPT.
T5 423-548 Sentence denotes The P. pastoris-derived mannosylation of the fusion protein aids rapid normal tissue clearance required for successful ADEPT.
TextSentencer_T6 549-718 Sentence denotes The work presented provides evidence that MFECP1 is cleared by the endocytic and phagocytic mannose receptor (MR), which is known to bind to mannose-terminating glycans.
T6 549-718 Sentence denotes The work presented provides evidence that MFECP1 is cleared by the endocytic and phagocytic mannose receptor (MR), which is known to bind to mannose-terminating glycans.
T6 549-718 Sentence denotes The work presented provides evidence that MFECP1 is cleared by the endocytic and phagocytic mannose receptor (MR), which is known to bind to mannose-terminating glycans.
TextSentencer_T7 719-824 Sentence denotes MR-transfected fibroblast cells internalize MFECP1 as revealed by flow cytometry and confocal microscopy.
T7 719-824 Sentence denotes MR-transfected fibroblast cells internalize MFECP1 as revealed by flow cytometry and confocal microscopy.
T7 719-824 Sentence denotes MR-transfected fibroblast cells internalize MFECP1 as revealed by flow cytometry and confocal microscopy.
TextSentencer_T8 825-1014 Sentence denotes Immunofluorescence microscopy shows that in vivo clearance in mice occurs predominantly by MR on liver sinusoidal endothelial cells, although MR is also expressed on adjacent Kupffer cells.
T8 825-1014 Sentence denotes Immunofluorescence microscopy shows that in vivo clearance in mice occurs predominantly by MR on liver sinusoidal endothelial cells, although MR is also expressed on adjacent Kupffer cells.
T8 825-1014 Sentence denotes Immunofluorescence microscopy shows that in vivo clearance in mice occurs predominantly by MR on liver sinusoidal endothelial cells, although MR is also expressed on adjacent Kupffer cells.
TextSentencer_T9 1015-1182 Sentence denotes In the spleen, MFECP1 is taken up by MR-expressing macrophages residing in the red pulp and not by dendritic cells which are found in the marginal zone and white pulp.
T9 1015-1182 Sentence denotes In the spleen, MFECP1 is taken up by MR-expressing macrophages residing in the red pulp and not by dendritic cells which are found in the marginal zone and white pulp.
T9 1015-1182 Sentence denotes In the spleen, MFECP1 is taken up by MR-expressing macrophages residing in the red pulp and not by dendritic cells which are found in the marginal zone and white pulp.
TextSentencer_T10 1183-1294 Sentence denotes Clearance can be inhibited in vivo by the MR inhibitor mannan as shown by increased enzyme activities in blood.
T10 1183-1294 Sentence denotes Clearance can be inhibited in vivo by the MR inhibitor mannan as shown by increased enzyme activities in blood.
T10 1183-1294 Sentence denotes Clearance can be inhibited in vivo by the MR inhibitor mannan as shown by increased enzyme activities in blood.
TextSentencer_T11 1295-1560 Sentence denotes The work improves understanding of interactions of MFECP1 with normal tissue, shows that glycosylation can be exploited in the design of recombinant anticancer therapeutics and opens the ways for optimizing pharmacokinetics of mannosylated recombinant therapeutics.
T11 1295-1560 Sentence denotes The work improves understanding of interactions of MFECP1 with normal tissue, shows that glycosylation can be exploited in the design of recombinant anticancer therapeutics and opens the ways for optimizing pharmacokinetics of mannosylated recombinant therapeutics.
T11 1295-1560 Sentence denotes The work improves understanding of interactions of MFECP1 with normal tissue, shows that glycosylation can be exploited in the design of recombinant anticancer therapeutics and opens the ways for optimizing pharmacokinetics of mannosylated recombinant therapeutics.