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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-220 Sentence denotes Hypogammaglobulinemia with a selective delayed recovery in memory B cells and an impaired isotype expression after rituximab administration as an adjuvant to autologous stem cell transplantation for non-Hodgkin lymphoma.
T1 0-220 Sentence denotes Hypogammaglobulinemia with a selective delayed recovery in memory B cells and an impaired isotype expression after rituximab administration as an adjuvant to autologous stem cell transplantation for non-Hodgkin lymphoma.
TextSentencer_T2 221-232 Sentence denotes OBJECTIVES:
T2 221-232 Sentence denotes OBJECTIVES:
TextSentencer_T3 233-399 Sentence denotes Some studies have indicated patients who received rituximab as adjuvant to stem cell transplantation had an increased risk of developing severe hypogammaglobulinemia.
T3 233-399 Sentence denotes Some studies have indicated patients who received rituximab as adjuvant to stem cell transplantation had an increased risk of developing severe hypogammaglobulinemia.
TextSentencer_T4 400-562 Sentence denotes The mechanism of this hypogammaglobulinemia is unknown, although investigators have hypothesized a further delay in the B-cell recovery as one potential etiology.
T4 400-562 Sentence denotes The mechanism of this hypogammaglobulinemia is unknown, although investigators have hypothesized a further delay in the B-cell recovery as one potential etiology.
TextSentencer_T5 563-646 Sentence denotes The aim of this study is to clarify the mechanism(s) of this hypogammaglobulinemia.
T5 563-646 Sentence denotes The aim of this study is to clarify the mechanism(s) of this hypogammaglobulinemia.
TextSentencer_T6 647-655 Sentence denotes METHODS:
T6 647-655 Sentence denotes METHODS:
TextSentencer_T7 656-785 Sentence denotes A total of 14 patients with high-risk CD20+ lymphoma underwent an autologous peripheral blood stem cell transplantation (APBSCT).
T7 656-785 Sentence denotes A total of 14 patients with high-risk CD20+ lymphoma underwent an autologous peripheral blood stem cell transplantation (APBSCT).
TextSentencer_T8 786-889 Sentence denotes After a hematological recovery, rituximab was given weekly for up to four doses as an adjuvant therapy.
T8 786-889 Sentence denotes After a hematological recovery, rituximab was given weekly for up to four doses as an adjuvant therapy.
TextSentencer_T9 890-898 Sentence denotes RESULTS:
T9 890-898 Sentence denotes RESULTS:
TextSentencer_T10 899-1083 Sentence denotes After a median follow up of 33.5 months, we found six patients (group A) who had hypogammaglobulinemia, while the eight other patients (group B) had normal serum immunoglobulin levels.
T10 899-1083 Sentence denotes After a median follow up of 33.5 months, we found six patients (group A) who had hypogammaglobulinemia, while the eight other patients (group B) had normal serum immunoglobulin levels.
TextSentencer_T11 1084-1176 Sentence denotes A phenotypical analysis revealed that group A patients had already achieved B-cell recovery.
T11 1084-1176 Sentence denotes A phenotypical analysis revealed that group A patients had already achieved B-cell recovery.
TextSentencer_T12 1177-1387 Sentence denotes However, we found a severe delay in the recovery of CD27+ memory B cells, especially in the IgD-/CD27+ switched populations in group A, but CD27 negative naive B-cells reverted to a normal range in both groups.
T12 1177-1387 Sentence denotes However, we found a severe delay in the recovery of CD27+ memory B cells, especially in the IgD-/CD27+ switched populations in group A, but CD27 negative naive B-cells reverted to a normal range in both groups.
TextSentencer_T13 1388-1597 Sentence denotes Consistent with this, reverse transcriptase-polymerase chain reaction studies with peripheral blood mononuclear cells revealed that most patients in group A lacked more than two classes of isotype transcripts.
T13 1388-1597 Sentence denotes Consistent with this, reverse transcriptase-polymerase chain reaction studies with peripheral blood mononuclear cells revealed that most patients in group A lacked more than two classes of isotype transcripts.
TextSentencer_T14 1598-1610 Sentence denotes CONCLUSIONS:
T14 1598-1610 Sentence denotes CONCLUSIONS:
TextSentencer_T15 1611-1864 Sentence denotes Abnormal repertoires and impaired isotype expression are seen in patients with common variable immunodeficiency, these data suggested that rituximab after APBSCT can affect not only the B-cell quantities, but also the recovery of the B-cell repertoires.
T15 1611-1864 Sentence denotes Abnormal repertoires and impaired isotype expression are seen in patients with common variable immunodeficiency, these data suggested that rituximab after APBSCT can affect not only the B-cell quantities, but also the recovery of the B-cell repertoires.