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PubMed:16897184 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-71 Sentence denotes Screening a series of sialyltransferases for possible BACE1 substrates.
T1 0-71 Sentence denotes Screening a series of sialyltransferases for possible BACE1 substrates.
TextSentencer_T2 72-211 Sentence denotes Deposition of amyloid beta-peptide (Abeta) and neurofibrillary tangles in the brain are hallmarks of Alzheimer's disease (AD) pathogenesis.
T2 72-211 Sentence denotes Deposition of amyloid beta-peptide (Abeta) and neurofibrillary tangles in the brain are hallmarks of Alzheimer's disease (AD) pathogenesis.
TextSentencer_T3 212-383 Sentence denotes BACE1, a membrane-bound aspartic protease that cleaves amyloid precursor protein (APP) to produce Abeta, has been implicated in triggering the pathogenesis of the disease.
T3 212-383 Sentence denotes BACE1, a membrane-bound aspartic protease that cleaves amyloid precursor protein (APP) to produce Abeta, has been implicated in triggering the pathogenesis of the disease.
TextSentencer_T4 384-532 Sentence denotes We previously reported that BACE1 also cleaved alpha2,6-sialyltransferase (ST6Gal I) in the Golgi apparatus and induced its secretion from the cell.
T4 384-532 Sentence denotes We previously reported that BACE1 also cleaved alpha2,6-sialyltransferase (ST6Gal I) in the Golgi apparatus and induced its secretion from the cell.
TextSentencer_T5 533-724 Sentence denotes Since most glycosyltransferases show Golgi localization and many of these are cleaved and secreted from the cell, we hypothesized that other glycosyltransferases may also be BACE1 substrates.
T5 533-724 Sentence denotes Since most glycosyltransferases show Golgi localization and many of these are cleaved and secreted from the cell, we hypothesized that other glycosyltransferases may also be BACE1 substrates.
TextSentencer_T6 725-811 Sentence denotes Here, we focused on a series of sialyltransferases as candidates for BACE1 substrates.
T6 725-811 Sentence denotes Here, we focused on a series of sialyltransferases as candidates for BACE1 substrates.
TextSentencer_T7 812-887 Sentence denotes We found that BACE1 cleaved polysialyltransferase ST8Sia IV (PST) in vitro.
T7 812-887 Sentence denotes We found that BACE1 cleaved polysialyltransferase ST8Sia IV (PST) in vitro.
TextSentencer_T8 888-1065 Sentence denotes We further found that BACE1 overexpression in COS cells enhanced the secretion of ST3Gal I, II, III and IV, although these sialyltransferases were not cleaved by BACE1 in vitro.
T8 888-1065 Sentence denotes We further found that BACE1 overexpression in COS cells enhanced the secretion of ST3Gal I, II, III and IV, although these sialyltransferases were not cleaved by BACE1 in vitro.
TextSentencer_T9 1066-1269 Sentence denotes These results suggest that BACE1 expression affects glycosylation not only by directly cleaving glycosyltransferases but also by modifying the secretion of glycosyltransferases via some other mechanisms.
T9 1066-1269 Sentence denotes These results suggest that BACE1 expression affects glycosylation not only by directly cleaving glycosyltransferases but also by modifying the secretion of glycosyltransferases via some other mechanisms.