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PubMed:1674745 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes Apolipoprotein E-4Philadelphia (Glu13----Lys,Arg145----Cys).
T1 0-60 Sentence denotes Apolipoprotein E-4Philadelphia (Glu13----Lys,Arg145----Cys).
T2 61-183 Sentence denotes Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia.
T2 61-183 Sentence denotes Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia.
T3 184-297 Sentence denotes The molecular defect in a 24-year-old white female with severe type III hyperlipoproteinemia has been elucidated.
T3 184-297 Sentence denotes The molecular defect in a 24-year-old white female with severe type III hyperlipoproteinemia has been elucidated.
T4 298-396 Sentence denotes The patient's apolipoprotein (apo) E migrated in the apoE-4 position on isoelectric focusing gels.
T4 298-396 Sentence denotes The patient's apolipoprotein (apo) E migrated in the apoE-4 position on isoelectric focusing gels.
T5 397-544 Sentence denotes On sodium dodecyl sulfate-polyacrylamide gel electrophoresis the apoE-4 variant had a smaller apparent molecular weight than apoE-4(Cys112----Arg).
T5 397-544 Sentence denotes On sodium dodecyl sulfate-polyacrylamide gel electrophoresis the apoE-4 variant had a smaller apparent molecular weight than apoE-4(Cys112----Arg).
T6 545-680 Sentence denotes Sequence analysis of DNA amplified with the polymerase chain reaction revealed two nucleotide substitutions in the proband's apoE gene.
T6 545-680 Sentence denotes Sequence analysis of DNA amplified with the polymerase chain reaction revealed two nucleotide substitutions in the proband's apoE gene.
T7 681-813 Sentence denotes A C to T mutation converted arginine (CGT) at position 145 of the mature protein to cysteine (TGT) thus creating the apoE-2 variant.
T7 681-813 Sentence denotes A C to T mutation converted arginine (CGT) at position 145 of the mature protein to cysteine (TGT) thus creating the apoE-2 variant.
T8 814-1008 Sentence denotes A second G to A substitution at amino acid 13 led to the exchange of lysine (AAG) for glutamic acid (GAG), thereby adding 2 positive charge units to the protein and producing the apoE-5 variant.
T8 814-1008 Sentence denotes A second G to A substitution at amino acid 13 led to the exchange of lysine (AAG) for glutamic acid (GAG), thereby adding 2 positive charge units to the protein and producing the apoE-5 variant.
T9 1009-1158 Sentence denotes Computer analysis of the apoE-4Philadelphia gene revealed that the G to A mutation in exon 3 resulted in the loss of an AvaI restriction enzyme site.
T9 1009-1158 Sentence denotes Computer analysis of the apoE-4Philadelphia gene revealed that the G to A mutation in exon 3 resulted in the loss of an AvaI restriction enzyme site.
T10 1159-1286 Sentence denotes The second mutation, a C to T substitution in the fourth exon of the apoE gene, eliminated a cleavage site for the enzyme BbvI.
T10 1159-1286 Sentence denotes The second mutation, a C to T substitution in the fourth exon of the apoE gene, eliminated a cleavage site for the enzyme BbvI.
T11 1287-1468 Sentence denotes Using these restriction fragment length polymorphisms as well as DNA sequence analysis we have demonstrated that the patient is homozygous for both point mutations in the apoE gene.
T11 1287-1468 Sentence denotes Using these restriction fragment length polymorphisms as well as DNA sequence analysis we have demonstrated that the patient is homozygous for both point mutations in the apoE gene.