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PubMed:16638841 JSONTXT 67 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-145 Sentence denotes Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.
T1 0-145 Sentence denotes Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.
TextSentencer_T2 146-296 Sentence denotes The bacterial hyaluronan lyases (Hyals) that degrade hyaluronan, an important component of the extracellular matrix, are involved in microbial spread.
T2 146-296 Sentence denotes The bacterial hyaluronan lyases (Hyals) that degrade hyaluronan, an important component of the extracellular matrix, are involved in microbial spread.
TextSentencer_T3 297-489 Sentence denotes Inhibitors of these enzymes are essential in investigation of the role of hyaluronan and Hyal in bacterial infections and constitute a new class of antibiotics against Hyal-producing bacteria.
T3 297-489 Sentence denotes Inhibitors of these enzymes are essential in investigation of the role of hyaluronan and Hyal in bacterial infections and constitute a new class of antibiotics against Hyal-producing bacteria.
TextSentencer_T4 490-607 Sentence denotes Recently, we identified 1,3-diacetylbenzimidazole-2-thione and related molecules as inhibitors of streptococcal Hyal.
T4 490-607 Sentence denotes Recently, we identified 1,3-diacetylbenzimidazole-2-thione and related molecules as inhibitors of streptococcal Hyal.
TextSentencer_T5 608-785 Sentence denotes One of such compounds, 1-decyl-2-(4-sulfamoyloxyphenyl)-1-indol-6-yl sulfamate, was co-crystallized in a complex with Streptococcus pneumoniae Hyal and its structure elucidated.
T5 608-785 Sentence denotes One of such compounds, 1-decyl-2-(4-sulfamoyloxyphenyl)-1-indol-6-yl sulfamate, was co-crystallized in a complex with Streptococcus pneumoniae Hyal and its structure elucidated.
TextSentencer_T6 786-964 Sentence denotes The resultant X-ray structure demonstrates that this inhibitor fits in the enzymatic active site via interactions resembling the binding mode of the natural hyaluronan substrate.
T6 786-964 Sentence denotes The resultant X-ray structure demonstrates that this inhibitor fits in the enzymatic active site via interactions resembling the binding mode of the natural hyaluronan substrate.
TextSentencer_T7 965-1112 Sentence denotes X-ray structural analysis also indicates binding interactions with the catalytic residues and those of a catalytically essential hydrophobic patch.
T7 965-1112 Sentence denotes X-ray structural analysis also indicates binding interactions with the catalytic residues and those of a catalytically essential hydrophobic patch.
TextSentencer_T8 1113-1286 Sentence denotes An IC50 value of 11 microM for Hyal from Streptococcus agalactiae (strain 4755) qualifies this phenylindole compound as one of the most potent Hyal inhibitors known to date.
T8 1113-1286 Sentence denotes An IC50 value of 11 microM for Hyal from Streptococcus agalactiae (strain 4755) qualifies this phenylindole compound as one of the most potent Hyal inhibitors known to date.
TextSentencer_T9 1287-1387 Sentence denotes The structural data suggested a similar binding mode for N-(3-phenylpropionyl)-benzoxazole-2-thione.
T9 1287-1387 Sentence denotes The structural data suggested a similar binding mode for N-(3-phenylpropionyl)-benzoxazole-2-thione.
TextSentencer_T10 1388-1518 Sentence denotes This new compound's inhibitory properties were confirmed resulting in discovery of yet another Hyal inhibitor (IC50 of 15 microM).
T10 1388-1518 Sentence denotes This new compound's inhibitory properties were confirmed resulting in discovery of yet another Hyal inhibitor (IC50 of 15 microM).
TextSentencer_T11 1519-1710 Sentence denotes These benzoxazole-2-thiones constitute a new class of inhibitors of bacterial Hyals and are well suited for further optimization of their selectivity, potency, and pharmacokinetic properties.
T11 1519-1710 Sentence denotes These benzoxazole-2-thiones constitute a new class of inhibitors of bacterial Hyals and are well suited for further optimization of their selectivity, potency, and pharmacokinetic properties.