| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-76 |
Sentence |
denotes |
Polymorphisms in human langerin affect stability and sugar binding activity. |
| T2 |
77-203 |
Sentence |
denotes |
Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. |
| T3 |
204-409 |
Sentence |
denotes |
Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells. |
| T4 |
410-518 |
Sentence |
denotes |
Langerin binds and mediates uptake and degradation of glycoconjugates containing mannose and related sugars. |
| T5 |
519-686 |
Sentence |
denotes |
Analysis of the human genome has identified three single nucleotide polymorphisms that result in amino acid changes in the carbohydrate-recognition domain of langerin. |
| T6 |
687-811 |
Sentence |
denotes |
The effects of the amino acid changes on the activity of langerin were examined by expressing each of the polymorphic forms. |
| T7 |
812-985 |
Sentence |
denotes |
Expression of full-length versions of the four common langerin haplotypes in fibroblasts revealed that all of these forms can mediate endocytosis of neoglycoprotein ligands. |
| T8 |
986-1275 |
Sentence |
denotes |
However, sugar binding assays and differential scanning calorimetry performed on fragments from the extracellular domain showed that two of the amino acid changes reduce the affinity of the carbohydrate-recognition domain for mannose and decrease the stability of the extracellular domain. |
| T9 |
1276-1486 |
Sentence |
denotes |
In addition, analysis of sugar binding by langerin containing the rare W264R mutation, previously identified in an individual lacking Birbeck granules, shows that this mutation abolishes sugar binding activity. |
| T10 |
1487-1646 |
Sentence |
denotes |
These findings suggest that certain langerin haplotypes may differ in their binding to pathogens and thus might be associated with susceptibility to infection. |
