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PubMed:16449349 JSONTXT 65 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-85 Sentence denotes Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination.
T1 0-85 Sentence denotes Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination.
T1 0-85 Sentence denotes Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for antitumor vaccination.
TextSentencer_T2 86-244 Sentence denotes In cancer, mucins are aberrantly O-glycosylated, and consequently, they express tumor-associated antigens such as the Tn determinant (alpha-GalNAc-O-Ser/Thr).
T2 86-244 Sentence denotes In cancer, mucins are aberrantly O-glycosylated, and consequently, they express tumor-associated antigens such as the Tn determinant (alpha-GalNAc-O-Ser/Thr).
T2 86-244 Sentence denotes In cancer, mucins are aberrantly O-glycosylated, and consequently, they express tumor-associated antigens such as the Tn determinant (alpha-GalNAc-O-Ser/Thr).
TextSentencer_T3 245-330 Sentence denotes As compared with normal tissues, they also exhibit a different pattern of expression.
T3 245-330 Sentence denotes As compared with normal tissues, they also exhibit a different pattern of expression.
T3 245-330 Sentence denotes As compared with normal tissues, they also exhibit a different pattern of expression.
TextSentencer_T4 331-483 Sentence denotes In particular, MUC6, which is normally expressed only in gastric tissues, has been detected in intestinal, pulmonary, colorectal, and breast carcinomas.
T4 331-483 Sentence denotes In particular, MUC6, which is normally expressed only in gastric tissues, has been detected in intestinal, pulmonary, colorectal, and breast carcinomas.
T4 331-483 Sentence denotes In particular, MUC6, which is normally expressed only in gastric tissues, has been detected in intestinal, pulmonary, colorectal, and breast carcinomas.
TextSentencer_T5 484-586 Sentence denotes Recently, we have shown that the MCF7 breast cancer cell line expresses MUC6-Tn glycoproteins in vivo.
T5 484-586 Sentence denotes Recently, we have shown that the MCF7 breast cancer cell line expresses MUC6-Tn glycoproteins in vivo.
T5 484-586 Sentence denotes Recently, we have shown that the MCF7 breast cancer cell line expresses MUC6-Tn glycoproteins in vivo.
TextSentencer_T6 587-728 Sentence denotes Cancer-associated mucins show antigenic differences from normal mucins, and as such, they may be used as potential targets for immunotherapy.
T6 587-728 Sentence denotes Cancer-associated mucins show antigenic differences from normal mucins, and as such, they may be used as potential targets for immunotherapy.
T6 587-728 Sentence denotes Cancer-associated mucins show antigenic differences from normal mucins, and as such, they may be used as potential targets for immunotherapy.
TextSentencer_T7 729-829 Sentence denotes To develop anticancer vaccines based on the Tn antigen, we prepared several MUC6-Tn glycoconjugates.
T7 729-829 Sentence denotes To develop anticancer vaccines based on the Tn antigen, we prepared several MUC6-Tn glycoconjugates.
T7 729-829 Sentence denotes To develop anticancer vaccines based on the Tn antigen, we prepared several MUC6-Tn glycoconjugates.
TextSentencer_T8 830-1093 Sentence denotes To this end, we performed the GalNAc enzymatic transfer to two recombinant MUC6 proteins expressed in Escherichia coli, using UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts), which catalyze in vivo the Tn antigen synthesis.
T8 830-1093 Sentence denotes To this end, we performed the GalNAc enzymatic transfer to two recombinant MUC6 proteins expressed in Escherichia coli, using UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts), which catalyze in vivo the Tn antigen synthesis.
T8 830-1093 Sentence denotes To this end, we performed the GalNAc enzymatic transfer to two recombinant MUC6 proteins expressed in Escherichia coli, using UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts), which catalyze in vivo the Tn antigen synthesis.
TextSentencer_T9 1094-1201 Sentence denotes We used either a mixture of ppGalNAc-Ts from MCF7 breast cancer cell extracts or a recombinant ppGalNAc-T1.
T9 1094-1201 Sentence denotes We used either a mixture of ppGalNAc-Ts from MCF7 breast cancer cell extracts or a recombinant ppGalNAc-T1.
T9 1094-1201 Sentence denotes We used either a mixture of ppGalNAc-Ts from MCF7 breast cancer cell extracts or a recombinant ppGalNAc-T1.
TextSentencer_T10 1202-1311 Sentence denotes In both cases, we achieved the synthesis of MUC6-Tn glycoconjugates at a semi-preparative scale (mg amounts).
T10 1202-1311 Sentence denotes In both cases, we achieved the synthesis of MUC6-Tn glycoconjugates at a semi-preparative scale (mg amounts).
T10 1202-1311 Sentence denotes In both cases, we achieved the synthesis of MUC6-Tn glycoconjugates at a semi-preparative scale (mg amounts).
TextSentencer_T11 1312-1451 Sentence denotes These glycoproteins displayed a high level of Tn antigens, although the overall density depends on both enzyme source and protein acceptor.
T11 1312-1451 Sentence denotes These glycoproteins displayed a high level of Tn antigens, although the overall density depends on both enzyme source and protein acceptor.
T11 1312-1451 Sentence denotes These glycoproteins displayed a high level of Tn antigens, although the overall density depends on both enzyme source and protein acceptor.
TextSentencer_T12 1452-1575 Sentence denotes These MUC6-Tn glycoconjugates were recognized by two anti-Tn monoclonal antibodies that are specific to human cancer cells.
T12 1452-1575 Sentence denotes These MUC6-Tn glycoconjugates were recognized by two anti-Tn monoclonal antibodies that are specific to human cancer cells.
T12 1452-1575 Sentence denotes These MUC6-Tn glycoconjugates were recognized by two anti-Tn monoclonal antibodies that are specific to human cancer cells.
TextSentencer_T13 1576-1764 Sentence denotes Moreover, the MUC6-Tn glycoconjugate glycosylated using MCF7 extracts as the ppGalNAc-T source was able to induce immunoglobulin G (IgG) antibodies that recognized a human tumor cell line.
T13 1576-1764 Sentence denotes Moreover, the MUC6-Tn glycoconjugate glycosylated using MCF7 extracts as the ppGalNAc-T source was able to induce immunoglobulin G (IgG) antibodies that recognized a human tumor cell line.
T13 1576-1764 Sentence denotes Moreover, the MUC6-Tn glycoconjugate glycosylated using MCF7 extracts as the ppGalNAc-T source was able to induce immunoglobulin G (IgG) antibodies that recognized a human tumor cell line.
TextSentencer_T14 1765-1988 Sentence denotes In conclusion, the large-scaled production of MUC6 with tumor-relevant glycoforms holds considerable promise for developing effective anticancer vaccines, and further studies of their immunological properties are warranted.
T14 1765-1988 Sentence denotes In conclusion, the large-scaled production of MUC6 with tumor-relevant glycoforms holds considerable promise for developing effective anticancer vaccines, and further studies of their immunological properties are warranted.
T14 1765-1988 Sentence denotes In conclusion, the large-scaled production of MUC6 with tumor-relevant glycoforms holds considerable promise for developing effective anticancer vaccines, and further studies of their immunological properties are warranted.