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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-134 Sentence denotes Peroxisomal proliferator activated receptor-gamma deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3).
T1 0-134 Sentence denotes Peroxisomal proliferator activated receptor-gamma deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3).
TextSentencer_T2 135-146 Sentence denotes BACKGROUND:
T2 135-146 Sentence denotes BACKGROUND:
TextSentencer_T3 147-351 Sentence denotes Familial partial lipodystrophy (Dunnigan) type 3 (FPLD3, Mendelian Inheritance in Man [MIM] 604367) results from heterozygous mutations in PPARG encoding peroxisomal proliferator-activated receptor-gamma.
T3 147-351 Sentence denotes Familial partial lipodystrophy (Dunnigan) type 3 (FPLD3, Mendelian Inheritance in Man [MIM] 604367) results from heterozygous mutations in PPARG encoding peroxisomal proliferator-activated receptor-gamma.
TextSentencer_T4 352-448 Sentence denotes Both dominant-negative and haploinsufficiency mechanisms have been suggested for this condition.
T4 352-448 Sentence denotes Both dominant-negative and haploinsufficiency mechanisms have been suggested for this condition.
TextSentencer_T5 449-457 Sentence denotes METHODS:
T5 449-457 Sentence denotes METHODS:
TextSentencer_T6 458-620 Sentence denotes We present a Canadian FPLD3 kindred with an affected mother who had loss of fat on arms and legs, but no increase in facial, neck, suprascapular or abdominal fat.
T6 458-620 Sentence denotes We present a Canadian FPLD3 kindred with an affected mother who had loss of fat on arms and legs, but no increase in facial, neck, suprascapular or abdominal fat.
TextSentencer_T7 621-884 Sentence denotes She had profound insulin resistance, diabetes, severe hypertriglyceridemia and relapsing pancreatitis, while her pre-pubescent daughter had normal fat distribution but elevated plasma triglycerides and C-peptide and depressed high-density lipoprotein cholesterol.
T7 621-884 Sentence denotes She had profound insulin resistance, diabetes, severe hypertriglyceridemia and relapsing pancreatitis, while her pre-pubescent daughter had normal fat distribution but elevated plasma triglycerides and C-peptide and depressed high-density lipoprotein cholesterol.
TextSentencer_T8 885-893 Sentence denotes RESULTS:
T8 885-893 Sentence denotes RESULTS:
TextSentencer_T9 894-1104 Sentence denotes The mother and daughter were each heterozygous for PPARG nonsense mutation Y355X, whose protein product in vitro was transcriptionally inactive with no dominant-negative activity against the wild-type receptor.
T9 894-1104 Sentence denotes The mother and daughter were each heterozygous for PPARG nonsense mutation Y355X, whose protein product in vitro was transcriptionally inactive with no dominant-negative activity against the wild-type receptor.
TextSentencer_T10 1105-1169 Sentence denotes In addition the mutant protein appeared to be markedly unstable.
T10 1105-1169 Sentence denotes In addition the mutant protein appeared to be markedly unstable.
TextSentencer_T11 1170-1181 Sentence denotes CONCLUSION:
T11 1170-1181 Sentence denotes CONCLUSION:
TextSentencer_T12 1182-1481 Sentence denotes Taken together with previous studies of human PPARG mutations, these findings suggest that PPAR-gamma deficiency due either to haploinsufficiency or to substantial activity loss due to dominant negative interference of the normal allele product's function can each contribute to the FPLD3 phenotype.
T12 1182-1481 Sentence denotes Taken together with previous studies of human PPARG mutations, these findings suggest that PPAR-gamma deficiency due either to haploinsufficiency or to substantial activity loss due to dominant negative interference of the normal allele product's function can each contribute to the FPLD3 phenotype.