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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-98 Sentence denotes Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells.
T1 0-98 Sentence denotes Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells.
TextSentencer_T2 99-227 Sentence denotes Galectins are implicated in a large variety of biological functions, many of which depend on their carbohydrate-binding ability.
T2 99-227 Sentence denotes Galectins are implicated in a large variety of biological functions, many of which depend on their carbohydrate-binding ability.
TextSentencer_T3 228-428 Sentence denotes Fifteen members of the family have been identified in vertebrates based on binding to galactose (Gal) that is mediated by one or two, evolutionarily conserved, carbohydrate-recognition domains (CRDs).
T3 228-428 Sentence denotes Fifteen members of the family have been identified in vertebrates based on binding to galactose (Gal) that is mediated by one or two, evolutionarily conserved, carbohydrate-recognition domains (CRDs).
TextSentencer_T4 429-564 Sentence denotes Variations in glycan structures expressed on glycoconjugates at the cell surface may, therefore, affect galectin binding and functions.
T4 429-564 Sentence denotes Variations in glycan structures expressed on glycoconjugates at the cell surface may, therefore, affect galectin binding and functions.
TextSentencer_T5 565-891 Sentence denotes To identify roles for different glycans in the binding of the three types of mammalian galectins to cells, we performed fluorescence cytometry at 4 degrees C with recombinant rat galectin-1, human galectin-3, and three forms of human galectin-8, to Chinese hamster ovary (CHO) cells and 12 different CHO glycosylation mutants.
T5 565-891 Sentence denotes To identify roles for different glycans in the binding of the three types of mammalian galectins to cells, we performed fluorescence cytometry at 4 degrees C with recombinant rat galectin-1, human galectin-3, and three forms of human galectin-8, to Chinese hamster ovary (CHO) cells and 12 different CHO glycosylation mutants.
TextSentencer_T6 892-987 Sentence denotes All galectin species bound to parent CHO cells and binding was inhibited >90% by 0.2 M lactose.
T6 892-987 Sentence denotes All galectin species bound to parent CHO cells and binding was inhibited >90% by 0.2 M lactose.
TextSentencer_T7 988-1084 Sentence denotes Galectin-8 isoforms with either a long or a short inter-CRD linker bound similarly to CHO cells.
T7 988-1084 Sentence denotes Galectin-8 isoforms with either a long or a short inter-CRD linker bound similarly to CHO cells.
TextSentencer_T8 1085-1257 Sentence denotes However, a truncated form of galectin-8 containing only the N-terminal CRD bound only weakly to CHO cells and the C-terminal galectin-8 CRD exhibited extremely low binding.
T8 1085-1257 Sentence denotes However, a truncated form of galectin-8 containing only the N-terminal CRD bound only weakly to CHO cells and the C-terminal galectin-8 CRD exhibited extremely low binding.
TextSentencer_T9 1258-1504 Sentence denotes Binding of the galectins to the different CHO glycosylation mutants revealed that complex N-glycans are the major ligands for each galectin except the N-terminal CRD of galectins-8, and also identified some fine differences in glycan recognition.
T9 1258-1504 Sentence denotes Binding of the galectins to the different CHO glycosylation mutants revealed that complex N-glycans are the major ligands for each galectin except the N-terminal CRD of galectins-8, and also identified some fine differences in glycan recognition.
TextSentencer_T10 1505-1690 Sentence denotes Interestingly, increased binding of galectin-1 at 4 degrees C correlated with increased propidium iodide (PI) uptake, whereas galectin-3 or -8 binding did not induce permeability to PI.
T10 1505-1690 Sentence denotes Interestingly, increased binding of galectin-1 at 4 degrees C correlated with increased propidium iodide (PI) uptake, whereas galectin-3 or -8 binding did not induce permeability to PI.
TextSentencer_T11 1691-1974 Sentence denotes The CHO glycosylation mutants with various repertoires of cell surface glycans are a useful tool for investigating galectin-cell interactions as they present complex and simple glycans in a natural mixture of multivalent protein and lipid glycoconjugates anchored in a cell membrane.
T11 1691-1974 Sentence denotes The CHO glycosylation mutants with various repertoires of cell surface glycans are a useful tool for investigating galectin-cell interactions as they present complex and simple glycans in a natural mixture of multivalent protein and lipid glycoconjugates anchored in a cell membrane.