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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Hydrophobic Man-1-P derivatives correct abnormal glycosylation in Type I congenital disorder of glycosylation fibroblasts.
T1 0-122 Sentence denotes Hydrophobic Man-1-P derivatives correct abnormal glycosylation in Type I congenital disorder of glycosylation fibroblasts.
T1 0-122 Sentence denotes Hydrophobic Man-1-P derivatives correct abnormal glycosylation in Type I congenital disorder of glycosylation fibroblasts.
TextSentencer_T2 123-242 Sentence denotes Patients with Type I congenital disorders of glycosylation (CDG-I) make incomplete lipid-linked oligosaccharides (LLO).
T2 123-242 Sentence denotes Patients with Type I congenital disorders of glycosylation (CDG-I) make incomplete lipid-linked oligosaccharides (LLO).
T2 123-242 Sentence denotes Patients with Type I congenital disorders of glycosylation (CDG-I) make incomplete lipid-linked oligosaccharides (LLO).
TextSentencer_T3 243-338 Sentence denotes These glycans are poorly transferred to proteins resulting in unoccupied glycosylation sequons.
T3 243-338 Sentence denotes These glycans are poorly transferred to proteins resulting in unoccupied glycosylation sequons.
T3 243-338 Sentence denotes These glycans are poorly transferred to proteins resulting in unoccupied glycosylation sequons.
TextSentencer_T4 339-496 Sentence denotes Mutations in phosphomannomutase (PMM2) cause CDG-Ia by reducing the activity of PMM, which converts mannose (Man)-6-P to Man-1-P before formation of GDP-Man.
T4 339-496 Sentence denotes Mutations in phosphomannomutase (PMM2) cause CDG-Ia by reducing the activity of PMM, which converts mannose (Man)-6-P to Man-1-P before formation of GDP-Man.
T4 339-777 Sentence denotes Mutations in phosphomannomutase (PMM2) cause CDG-Ia by reducing the activity of PMM, which converts mannose (Man)-6-P to Man-1-P before formation of GDP-Man. These patients have reduced Man-1-P and GDP-Man. To replenish intracellular Man-1-P pools in CDG-Ia cells, we synthesized two hydrophobic, membrane permeable acylated versions of Man-1-P and determined their ability to normalize LLO size and N-glycosylation in CDG-Ia fibroblasts.
TextSentencer_T5 497-545 Sentence denotes These patients have reduced Man-1-P and GDP-Man.
T5 497-545 Sentence denotes These patients have reduced Man-1-P and GDP-Man.
TextSentencer_T6 546-777 Sentence denotes To replenish intracellular Man-1-P pools in CDG-Ia cells, we synthesized two hydrophobic, membrane permeable acylated versions of Man-1-P and determined their ability to normalize LLO size and N-glycosylation in CDG-Ia fibroblasts.
T6 546-777 Sentence denotes To replenish intracellular Man-1-P pools in CDG-Ia cells, we synthesized two hydrophobic, membrane permeable acylated versions of Man-1-P and determined their ability to normalize LLO size and N-glycosylation in CDG-Ia fibroblasts.
TextSentencer_T7 778-1059 Sentence denotes Both compounds, compound I (diacetoxymethyl 2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl phosphate) (C-I) and compound II (diacetoxymethyl 2,3,4,6-tetra-O-ethyloxycarbonyl-alpha-D-mannopyranosyl phosphate) (C-II), contain two acetoxymethyl (CH2OAc) groups O-linked to phosphorous.
T5 778-1059 Sentence denotes Both compounds, compound I (diacetoxymethyl 2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl phosphate) (C-I) and compound II (diacetoxymethyl 2,3,4,6-tetra-O-ethyloxycarbonyl-alpha-D-mannopyranosyl phosphate) (C-II), contain two acetoxymethyl (CH2OAc) groups O-linked to phosphorous.
T7 778-1059 Sentence denotes Both compounds, compound I (diacetoxymethyl 2,3,4,6-tetra-O-acetyl-alpha-D-mannopyranosyl phosphate) (C-I) and compound II (diacetoxymethyl 2,3,4,6-tetra-O-ethyloxycarbonyl-alpha-D-mannopyranosyl phosphate) (C-II), contain two acetoxymethyl (CH2OAc) groups O-linked to phosphorous.
TextSentencer_T8 1060-1154 Sentence denotes C-I contains acetyl esters and C-II contains ethylcarbonate (CO2Et) esters on the Man residue.
T6 1060-1154 Sentence denotes C-I contains acetyl esters and C-II contains ethylcarbonate (CO2Et) esters on the Man residue.
T8 1060-1154 Sentence denotes C-I contains acetyl esters and C-II contains ethylcarbonate (CO2Et) esters on the Man residue.
TextSentencer_T9 1155-1249 Sentence denotes Both C-I and C-II normalized truncated LLO, but C-II was about 2-fold more efficient than C-I.
T9 1155-1249 Sentence denotes Both C-I and C-II normalized truncated LLO, but C-II was about 2-fold more efficient than C-I.
T7 1155-1409 Sentence denotes Both C-I and C-II normalized truncated LLO, but C-II was about 2-fold more efficient than C-I. C-II replenished the GDP-Man pool in CDG-Ia cells and was more efficiently incorporated into glycoproteins than exogenous Man at low concentrations (25-75 mM).
TextSentencer_T10 1250-1409 Sentence denotes C-II replenished the GDP-Man pool in CDG-Ia cells and was more efficiently incorporated into glycoproteins than exogenous Man at low concentrations (25-75 mM).
T10 1250-1409 Sentence denotes C-II replenished the GDP-Man pool in CDG-Ia cells and was more efficiently incorporated into glycoproteins than exogenous Man at low concentrations (25-75 mM).
TextSentencer_T11 1410-1513 Sentence denotes In a glycosylation assay of DNaseI in CDG-Ia cells, C-II restored glycosylation to control cell levels.
T8 1410-1513 Sentence denotes In a glycosylation assay of DNaseI in CDG-Ia cells, C-II restored glycosylation to control cell levels.
T11 1410-1513 Sentence denotes In a glycosylation assay of DNaseI in CDG-Ia cells, C-II restored glycosylation to control cell levels.
TextSentencer_T12 1514-1841 Sentence denotes C-II also corrected impaired LLO biosynthesis in cells from a Dolichol (Dol)-P-Man deficient patient (CDG-Ie) and partially corrected LLO in cells from an ALG12 mannosyltransferase-deficient patient (CDG-Ig), whereas cells from an ALG3-deficient patient (CDG-Id) and from an MPDU1-deficient patient (CDG-If) were not corrected.
T9 1514-1841 Sentence denotes C-II also corrected impaired LLO biosynthesis in cells from a Dolichol (Dol)-P-Man deficient patient (CDG-Ie) and partially corrected LLO in cells from an ALG12 mannosyltransferase-deficient patient (CDG-Ig), whereas cells from an ALG3-deficient patient (CDG-Id) and from an MPDU1-deficient patient (CDG-If) were not corrected.
T12 1514-1841 Sentence denotes C-II also corrected impaired LLO biosynthesis in cells from a Dolichol (Dol)-P-Man deficient patient (CDG-Ie) and partially corrected LLO in cells from an ALG12 mannosyltransferase-deficient patient (CDG-Ig), whereas cells from an ALG3-deficient patient (CDG-Id) and from an MPDU1-deficient patient (CDG-If) were not corrected.
TextSentencer_T13 1842-1962 Sentence denotes These results validate the general concept of using pro-Man-1-P substrates as potential therapeutics for CDG-I patients.
T10 1842-1962 Sentence denotes These results validate the general concept of using pro-Man-1-P substrates as potential therapeutics for CDG-I patients.
T13 1842-1962 Sentence denotes These results validate the general concept of using pro-Man-1-P substrates as potential therapeutics for CDG-I patients.