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PubMed:15868402 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-68 Sentence denotes Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.
T1 0-68 Sentence denotes Poly(ADP-ribosyl)ation in relation to cancer and autoimmune disease.
TextSentencer_T2 69-171 Sentence denotes Carcinogenesis involves multiple steps and pathways with functional alterations in a variety of genes.
T2 69-171 Sentence denotes Carcinogenesis involves multiple steps and pathways with functional alterations in a variety of genes.
TextSentencer_T3 172-383 Sentence denotes There is accumulating evidence that a deficiency of poly(ADP-ribose) polymerase (PARP)-1 leads to DNA repair defects, genomic instability, failure of induction of cell death and modulation of gene transcription.
T3 172-383 Sentence denotes There is accumulating evidence that a deficiency of poly(ADP-ribose) polymerase (PARP)-1 leads to DNA repair defects, genomic instability, failure of induction of cell death and modulation of gene transcription.
TextSentencer_T4 384-453 Sentence denotes PARP-1 also supports the growth of tumor cells in certain situations.
T4 384-453 Sentence denotes PARP-1 also supports the growth of tumor cells in certain situations.
TextSentencer_T5 454-707 Sentence denotes Genetic analyses of the PARP-1 gene have demonstrated alterations in neoplasms, and a mutation affecting the conserved amino acid E251 in germ cell tumors, as well as an association of a single-nucleotide polymorphism V762A with risk of prostate cancer.
T5 454-707 Sentence denotes Genetic analyses of the PARP-1 gene have demonstrated alterations in neoplasms, and a mutation affecting the conserved amino acid E251 in germ cell tumors, as well as an association of a single-nucleotide polymorphism V762A with risk of prostate cancer.
TextSentencer_T6 708-978 Sentence denotes Recent development of a selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG), the enzyme primarily responsible for degradation of poly(ADP-ribose), and PARG-deficient animals should facilitate studies of the relationship of poly(ADP-ribose) with carcinogenesis.
T6 708-978 Sentence denotes Recent development of a selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG), the enzyme primarily responsible for degradation of poly(ADP-ribose), and PARG-deficient animals should facilitate studies of the relationship of poly(ADP-ribose) with carcinogenesis.
TextSentencer_T7 979-1148 Sentence denotes Inhibitors of PARP have also suggested roles in the pathogenesis of autoimmune disease, and a promoter haplotype of PARP-1 confers a higher risk of rheumatoid arthritis.
T7 979-1148 Sentence denotes Inhibitors of PARP have also suggested roles in the pathogenesis of autoimmune disease, and a promoter haplotype of PARP-1 confers a higher risk of rheumatoid arthritis.
TextSentencer_T8 1149-1296 Sentence denotes Further analysis of PARP-1, PARG and other PARP family genes should extend our understanding of the pathogenesis of cancer and autoimmune diseases.
T8 1149-1296 Sentence denotes Further analysis of PARP-1, PARG and other PARP family genes should extend our understanding of the pathogenesis of cancer and autoimmune diseases.
TextSentencer_T9 1297-1482 Sentence denotes Furthermore, there is potential for sensitization to chemo- and radiation therapy of cancers as well as the treatment of autoimmune disease with development of stronger PARP inhibitors.
T9 1297-1482 Sentence denotes Furthermore, there is potential for sensitization to chemo- and radiation therapy of cancers as well as the treatment of autoimmune disease with development of stronger PARP inhibitors.