> top > projects > sentences > docs > PubMed:15833836 > annotations
sentences Home  

PubMed:15833836 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-171 Sentence denotes Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
T1 0-171 Sentence denotes Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter.
TextSentencer_T2 172-442 Sentence denotes In breast cancer, overexpression of the small heat shock protein, HSP-27, is associated with increased anchorage-independent growth, increased invasiveness, and resistance to chemotherapeutic drugs and is associated with poor prognosis and reduced disease-free survival.
T2 172-442 Sentence denotes In breast cancer, overexpression of the small heat shock protein, HSP-27, is associated with increased anchorage-independent growth, increased invasiveness, and resistance to chemotherapeutic drugs and is associated with poor prognosis and reduced disease-free survival.
TextSentencer_T3 443-578 Sentence denotes Therefore, factors that increase the expression of HSP-27 in breast cancer are likely to affect the prognosis and outcome of treatment.
T3 443-578 Sentence denotes Therefore, factors that increase the expression of HSP-27 in breast cancer are likely to affect the prognosis and outcome of treatment.
TextSentencer_T4 579-797 Sentence denotes In this study, we show a strong correlation between elevated levels of the Brn-3b POU transcription factor and high levels of HSP-27 protein in manipulated MCF-7 breast cancer cells as well as in human breast biopsies.
T4 579-797 Sentence denotes In this study, we show a strong correlation between elevated levels of the Brn-3b POU transcription factor and high levels of HSP-27 protein in manipulated MCF-7 breast cancer cells as well as in human breast biopsies.
TextSentencer_T5 798-848 Sentence denotes Conversely, HSP-27 is decreased on loss of Brn-3b.
T5 798-848 Sentence denotes Conversely, HSP-27 is decreased on loss of Brn-3b.
TextSentencer_T6 849-991 Sentence denotes In cotransfection assays, Brn-3b can strongly transactivate the HSP-27 promoter, supporting a role for direct regulation of HSP-27 expression.
T6 849-991 Sentence denotes In cotransfection assays, Brn-3b can strongly transactivate the HSP-27 promoter, supporting a role for direct regulation of HSP-27 expression.
TextSentencer_T7 992-1228 Sentence denotes Brn-3b also cooperates with the estrogen receptor (ER) to facilitate maximal stimulation of the HSP-27 promoter, with significantly enhanced activity of this promoter observed on coexpression of Brn-3b and ER compared with either alone.
T7 992-1228 Sentence denotes Brn-3b also cooperates with the estrogen receptor (ER) to facilitate maximal stimulation of the HSP-27 promoter, with significantly enhanced activity of this promoter observed on coexpression of Brn-3b and ER compared with either alone.
TextSentencer_T8 1229-1437 Sentence denotes RNA interference and site-directed mutagenesis support the requirement for the Brn-3b binding site on the HSP-27 promoter, which facilitates maximal transactivation either alone or on interaction with the ER.
T8 1229-1437 Sentence denotes RNA interference and site-directed mutagenesis support the requirement for the Brn-3b binding site on the HSP-27 promoter, which facilitates maximal transactivation either alone or on interaction with the ER.
TextSentencer_T9 1438-1556 Sentence denotes Chromatin immunoprecipitation provides evidence for association of Brn-3b with the HSP-27 promoter in the intact cell.
T9 1438-1556 Sentence denotes Chromatin immunoprecipitation provides evidence for association of Brn-3b with the HSP-27 promoter in the intact cell.
TextSentencer_T10 1557-1755 Sentence denotes Thus, Brn-3b can, directly and indirectly (via interaction with the ER), activate HSP-27 expression, and this may represent one mechanism by which Brn-3b mediates its effects in breast cancer cells.
T10 1557-1755 Sentence denotes Thus, Brn-3b can, directly and indirectly (via interaction with the ER), activate HSP-27 expression, and this may represent one mechanism by which Brn-3b mediates its effects in breast cancer cells.