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PubMed:15797649 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-180 Sentence denotes Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion.
T1 0-180 Sentence denotes Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion.
TextSentencer_T2 181-192 Sentence denotes BACKGROUND:
T2 181-192 Sentence denotes BACKGROUND:
TextSentencer_T3 193-238 Sentence denotes Preeclampsia affects 3-5% of all pregnancies.
T3 193-238 Sentence denotes Preeclampsia affects 3-5% of all pregnancies.
TextSentencer_T4 239-305 Sentence denotes It is a major cause of maternal and fetal morbidity and mortality.
T4 239-305 Sentence denotes It is a major cause of maternal and fetal morbidity and mortality.
TextSentencer_T5 306-454 Sentence denotes Recent studies demonstrate that autoantibodies against the angiotensin II type 1 (AT(1)) receptor are present in the serum of preeclamptic patients.
T5 306-454 Sentence denotes Recent studies demonstrate that autoantibodies against the angiotensin II type 1 (AT(1)) receptor are present in the serum of preeclamptic patients.
TextSentencer_T6 455-657 Sentence denotes In this study, we investigated the role of AT(1) receptor-agonistic autoantibody (AT1-AA) regarding interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (Pai-1) secretion in human mesangial cells.
T6 455-657 Sentence denotes In this study, we investigated the role of AT(1) receptor-agonistic autoantibody (AT1-AA) regarding interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (Pai-1) secretion in human mesangial cells.
TextSentencer_T7 658-666 Sentence denotes METHODS:
T7 658-666 Sentence denotes METHODS:
TextSentencer_T8 667-764 Sentence denotes The study included ten patients: five severely preeclamptic and five normotensive pregnant women.
T8 667-764 Sentence denotes The study included ten patients: five severely preeclamptic and five normotensive pregnant women.
TextSentencer_T9 765-822 Sentence denotes Immunoglobulin-G (IgG) was purified from each individual.
T9 765-822 Sentence denotes Immunoglobulin-G (IgG) was purified from each individual.
TextSentencer_T10 823-962 Sentence denotes The presence of AT1-AA was determined based on its ability to stimulate an increase in the contraction rate of rat neonatal cardiomyocytes.
T10 823-962 Sentence denotes The presence of AT1-AA was determined based on its ability to stimulate an increase in the contraction rate of rat neonatal cardiomyocytes.
TextSentencer_T11 963-1054 Sentence denotes Primary human mesangial cells were chosen to study IgG-induced secretion of IL-6 and Pai-1.
T11 963-1054 Sentence denotes Primary human mesangial cells were chosen to study IgG-induced secretion of IL-6 and Pai-1.
TextSentencer_T12 1055-1266 Sentence denotes Losartan and epitope peptides were used to determine whether AT1-AA interaction with AT(1) receptor was associated with stimulation of IL-6 and Pai-1 secretion and was mediated through AT(1) receptor activation.
T12 1055-1266 Sentence denotes Losartan and epitope peptides were used to determine whether AT1-AA interaction with AT(1) receptor was associated with stimulation of IL-6 and Pai-1 secretion and was mediated through AT(1) receptor activation.
TextSentencer_T13 1267-1275 Sentence denotes RESULTS:
T13 1267-1275 Sentence denotes RESULTS:
TextSentencer_T14 1276-1383 Sentence denotes The IgG from preeclamptic patients stimulated an increased contraction rate in rat neonatal cardiomyocytes.
T14 1276-1383 Sentence denotes The IgG from preeclamptic patients stimulated an increased contraction rate in rat neonatal cardiomyocytes.
TextSentencer_T15 1384-1597 Sentence denotes The IgG from preeclamptic patients induced the AT(1) receptor-specific secretion of IL-6 and Pai-1 from human mesangial cells at a significantly higher level than that achieved with IgG from normotensive patients.
T15 1384-1597 Sentence denotes The IgG from preeclamptic patients induced the AT(1) receptor-specific secretion of IL-6 and Pai-1 from human mesangial cells at a significantly higher level than that achieved with IgG from normotensive patients.
TextSentencer_T16 1598-1693 Sentence denotes Competition with an epitope peptide suggested that the AT(1) receptor was stimulated by AT1-AA.
T16 1598-1693 Sentence denotes Competition with an epitope peptide suggested that the AT(1) receptor was stimulated by AT1-AA.
TextSentencer_T17 1694-1706 Sentence denotes CONCLUSIONS:
T17 1694-1706 Sentence denotes CONCLUSIONS:
TextSentencer_T18 1707-1880 Sentence denotes Our findings suggest that a maternal autoantibody with the ability to activate AT(1) receptors may account for the development of renal damage seen in preeclamptic patients.
T18 1707-1880 Sentence denotes Our findings suggest that a maternal autoantibody with the ability to activate AT(1) receptors may account for the development of renal damage seen in preeclamptic patients.