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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-176 Sentence denotes Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
T1 0-176 Sentence denotes Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
T1 0-176 Sentence denotes Role for up-regulated ganglioside biosynthesis and association of Src family kinases with microdomains in retinoic acid-induced differentiation of F9 embryonal carcinoma cells.
TextSentencer_T2 177-464 Sentence denotes Mouse F9 embryonal carcinoma cells have been widely used as a model for studying the mechanism of embryonic differentiation, because they are similar to the inner cell mass of early mouse embryos and can differentiate into primitive endoderm (PrE) following retinoic acid (RA) treatment.
T2 177-464 Sentence denotes Mouse F9 embryonal carcinoma cells have been widely used as a model for studying the mechanism of embryonic differentiation, because they are similar to the inner cell mass of early mouse embryos and can differentiate into primitive endoderm (PrE) following retinoic acid (RA) treatment.
T2 177-464 Sentence denotes Mouse F9 embryonal carcinoma cells have been widely used as a model for studying the mechanism of embryonic differentiation, because they are similar to the inner cell mass of early mouse embryos and can differentiate into primitive endoderm (PrE) following retinoic acid (RA) treatment.
TextSentencer_T3 465-618 Sentence denotes During F9 cell differentiation, the carbohydrate chains of glycoproteins and their corresponding glycosyltransferases are known to undergo rapid changes.
T3 465-618 Sentence denotes During F9 cell differentiation, the carbohydrate chains of glycoproteins and their corresponding glycosyltransferases are known to undergo rapid changes.
T3 465-618 Sentence denotes During F9 cell differentiation, the carbohydrate chains of glycoproteins and their corresponding glycosyltransferases are known to undergo rapid changes.
TextSentencer_T4 619-703 Sentence denotes However, there have been no corresponding reports on the expression of gangliosides.
T4 619-703 Sentence denotes However, there have been no corresponding reports on the expression of gangliosides.
T4 619-703 Sentence denotes However, there have been no corresponding reports on the expression of gangliosides.
TextSentencer_T5 704-843 Sentence denotes We have developed a custom cDNA array that is highly sensitive for the genes responsible for sphingolipid (SL) biosynthesis and metabolism.
T5 704-843 Sentence denotes We have developed a custom cDNA array that is highly sensitive for the genes responsible for sphingolipid (SL) biosynthesis and metabolism.
T5 704-843 Sentence denotes We have developed a custom cDNA array that is highly sensitive for the genes responsible for sphingolipid (SL) biosynthesis and metabolism.
TextSentencer_T6 844-966 Sentence denotes Using this, we found that, of the 28 selected genes, 26 exhibited increased expression during F9 differentiation into PrE.
T6 844-966 Sentence denotes Using this, we found that, of the 28 selected genes, 26 exhibited increased expression during F9 differentiation into PrE.
T6 844-966 Sentence denotes Using this, we found that, of the 28 selected genes, 26 exhibited increased expression during F9 differentiation into PrE.
TextSentencer_T7 967-1157 Sentence denotes Although neutral glycosphingolipids (GSLs) were expressed at similar levels before and after differentiation, a greater than 20-fold increase in total ganglioside content was evident in PrE.
T7 967-1157 Sentence denotes Although neutral glycosphingolipids (GSLs) were expressed at similar levels before and after differentiation, a greater than 20-fold increase in total ganglioside content was evident in PrE.
T7 967-1157 Sentence denotes Although neutral glycosphingolipids (GSLs) were expressed at similar levels before and after differentiation, a greater than 20-fold increase in total ganglioside content was evident in PrE.
TextSentencer_T8 1158-1433 Sentence denotes Glucosylceramide synthase inhibitors (d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol [d-PDMP] and its analog) depleted gangliosides and this resulted in delayed expression of Disabled-2 (Dab-2), suggesting the involvement of gangliosides in F9 cell differentiation.
T8 1158-1433 Sentence denotes Glucosylceramide synthase inhibitors (d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol [d-PDMP] and its analog) depleted gangliosides and this resulted in delayed expression of Disabled-2 (Dab-2), suggesting the involvement of gangliosides in F9 cell differentiation.
T8 1158-1433 Sentence denotes Glucosylceramide synthase inhibitors (d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol [d-PDMP] and its analog) depleted gangliosides and this resulted in delayed expression of Disabled-2 (Dab-2), suggesting the involvement of gangliosides in F9 cell differentiation.
TextSentencer_T9 1434-1558 Sentence denotes Disruption of cholesterol-enriched membrane microdomains by methyl-beta-cyclodextrin (MbetaCD) also delayed differentiation.
T9 1434-1558 Sentence denotes Disruption of cholesterol-enriched membrane microdomains by methyl-beta-cyclodextrin (MbetaCD) also delayed differentiation.
T9 1434-1558 Sentence denotes Disruption of cholesterol-enriched membrane microdomains by methyl-beta-cyclodextrin (MbetaCD) also delayed differentiation.
TextSentencer_T10 1559-1653 Sentence denotes Both MbetaCD and d-PDMP blocked the accumulation of Src family kinases (SFKs) to microdomains.
T10 1559-1653 Sentence denotes Both MbetaCD and d-PDMP blocked the accumulation of Src family kinases (SFKs) to microdomains.
T10 1559-1653 Sentence denotes Both MbetaCD and d-PDMP blocked the accumulation of Src family kinases (SFKs) to microdomains.
TextSentencer_T11 1654-1724 Sentence denotes However, d-PDMP did not block flotillin accumulation, yet MbetaCD did.
T11 1654-1724 Sentence denotes However, d-PDMP did not block flotillin accumulation, yet MbetaCD did.
T11 1654-1724 Sentence denotes However, d-PDMP did not block flotillin accumulation, yet MbetaCD did.
TextSentencer_T12 1725-1902 Sentence denotes Additionally, confocal laser microscopy revealed the formation of distinct functional microdomains integrating SFKs with gangliosides and cholesterol during PrE differentiation.
T12 1725-1902 Sentence denotes Additionally, confocal laser microscopy revealed the formation of distinct functional microdomains integrating SFKs with gangliosides and cholesterol during PrE differentiation.
T12 1725-1902 Sentence denotes Additionally, confocal laser microscopy revealed the formation of distinct functional microdomains integrating SFKs with gangliosides and cholesterol during PrE differentiation.
TextSentencer_T13 1903-2126 Sentence denotes Thus, we demonstrate the outstanding up-regulation of ganglioside biosynthesis and its importance in the formation of distinct microdomains incorporating SFKs with gangliosides during RA-induced differentiation of F9 cells.
T13 1903-2126 Sentence denotes Thus, we demonstrate the outstanding up-regulation of ganglioside biosynthesis and its importance in the formation of distinct microdomains incorporating SFKs with gangliosides during RA-induced differentiation of F9 cells.
T13 1903-2126 Sentence denotes Thus, we demonstrate the outstanding up-regulation of ganglioside biosynthesis and its importance in the formation of distinct microdomains incorporating SFKs with gangliosides during RA-induced differentiation of F9 cells.