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PubMed:15788408 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-127 Sentence denotes The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.
T2 128-348 Sentence denotes Aberrant retinal expression of vascular endothelial growth factor (VEGF) leading to neovascularization is a central feature of age-related macular degeneration and diabetic retinopathy, two leading causes of vision loss.
T3 349-542 Sentence denotes Oxidative stress is suggested to occur in retinal tissue during age-related macular degeneration and diabetic retinopathy and is suspected in the mechanism of VEGF expression in these diseases.
T4 543-652 Sentence denotes Arsenite, a thiol-reactive oxidative stressor, induces VEGF expression by a HIF-1alpha-independent mechanism.
T5 653-831 Sentence denotes Previously, we demonstrated that homocysteine, an endoplasmic reticulum stressor, increases VEGF transcription by a mechanism dependent upon activating transcription factor ATF4.
T6 832-995 Sentence denotes Because ATF4 is expressed in response to oxidative stress, we hypothesized that ATF4 was also responsible for increased VEGF transcription in response to arsenite.
T7 996-1124 Sentence denotes We now show that arsenite increased steady state levels of VEGF mRNA and activated transcription from a VEGF promoter construct.
T8 1125-1212 Sentence denotes Arsenite induced eIF2alpha phosphorylation, resulting in increased ATF4 protein levels.
T9 1213-1301 Sentence denotes Inactivation or loss of ATF4 greatly diminished the VEGF response to arsenite treatment.
T10 1302-1448 Sentence denotes Overexpression of ATF4 was sufficient to activate the VEGF promoter, and arsenite cooperated with exogenous ATF4 to further activate the promoter.
T11 1449-1614 Sentence denotes A complex containing ATF4 binds a DNA element at +1767 bp relative to the VEGF transcription start site, and DNA binding activity is increased by arsenite treatment.
T12 1615-1830 Sentence denotes In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression.
T13 1831-1933 Sentence denotes Thus, arsenite-induced up-regulation of VEGF gene transcription occurs by an ATF4-dependent mechanism.