| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-171 |
Sentence |
denotes |
Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. |
| T2 |
172-327 |
Sentence |
denotes |
We report here the role of one of the less studied members of the family of suppressors of cytokine signaling (SOCS), namely SOCS-7, in cytokine signaling. |
| T3 |
328-488 |
Sentence |
denotes |
We demonstrate that SOCS-7 inhibits prolactin (PRL), growth hormone (GH), or leptin (LEP) signaling mediated through STAT3 and STAT5 in a dose-dependent manner. |
| T4 |
489-604 |
Sentence |
denotes |
SOCS-7 also attenuated STAT3 and STAT5 signaling induced by overexpression of JH1, the catalytic subdomain of JAK2. |
| T5 |
605-723 |
Sentence |
denotes |
Since SOCS-7 interacted with phosphorylated STAT3 or STAT5, we assumed that SOCS-7 acts at the level of STAT proteins. |
| T6 |
724-878 |
Sentence |
denotes |
Indeed, we showed that SOCS-7 inhibits PRL- and leptin-induced STAT5 and STAT3 phosphorylation and prevented the nuclear translocation of activated STAT3. |
| T7 |
879-1139 |
Sentence |
denotes |
Taken together, our results indicate that SOCS-7 is a physiological dysregulator of PRL, leptin, and probably also GH signaling and that its mode of action is a novel variation of SOCS protein inhibition of cytokine-inducible STAT-mediated signal transduction. |
