> top > projects > sentences > docs > PubMed:15590773 > annotations
sentences Home  

PubMed:15590773 JSONTXT 46 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-250 Sentence denotes Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity.
T1 0-250 Sentence denotes Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity.
T1 0-250 Sentence denotes Selective cleavage and anticoagulant activity of a sulfated fucan: stereospecific removal of a 2-sulfate ester from the polysaccharide by mild acid hydrolysis, preparation of oligosaccharides, and heparin cofactor II-dependent anticoagulant activity.
TextSentencer_T2 251-531 Sentence denotes A linear sulfated fucan with a regular repeating sequence of [3)-alpha-L-Fucp-(2SO4)-(1-->3)-alpha-L-Fucp-(4SO4)-(1-->3)-alpha-L-Fucp-(2,4SO4)-(1-->3)-alpha-L-Fucp-(2SO4)-(1-->]n is an anticoagulant polysaccharide mainly due to thrombin inhibition mediated by heparin cofactor II.
T2 251-531 Sentence denotes A linear sulfated fucan with a regular repeating sequence of [3)-alpha-L-Fucp-(2SO4)-(1-->3)-alpha-L-Fucp-(4SO4)-(1-->3)-alpha-L-Fucp-(2,4SO4)-(1-->3)-alpha-L-Fucp-(2SO4)-(1-->]n is an anticoagulant polysaccharide mainly due to thrombin inhibition mediated by heparin cofactor II.
T2 251-531 Sentence denotes A linear sulfated fucan with a regular repeating sequence of [3)-alpha-L-Fucp-(2SO4)-(1-->3)-alpha-L-Fucp-(4SO4)-(1-->3)-alpha-L-Fucp-(2,4SO4)-(1-->3)-alpha-L-Fucp-(2SO4)-(1-->]n is an anticoagulant polysaccharide mainly due to thrombin inhibition mediated by heparin cofactor II.
TextSentencer_T3 532-656 Sentence denotes No specific enzymatic or chemical method is available for the preparation of tailored oligosaccharides from sulfated fucans.
T3 532-656 Sentence denotes No specific enzymatic or chemical method is available for the preparation of tailored oligosaccharides from sulfated fucans.
T3 532-656 Sentence denotes No specific enzymatic or chemical method is available for the preparation of tailored oligosaccharides from sulfated fucans.
TextSentencer_T4 657-767 Sentence denotes We employ an apparently nonspecific approach to cleave this polysaccharide based on mild hydrolysis with acid.
T4 657-767 Sentence denotes We employ an apparently nonspecific approach to cleave this polysaccharide based on mild hydrolysis with acid.
T4 657-767 Sentence denotes We employ an apparently nonspecific approach to cleave this polysaccharide based on mild hydrolysis with acid.
TextSentencer_T5 768-867 Sentence denotes Surprisingly, the linear sulfated fucan was cleaved by mild acid hydrolysis on an ordered sequence.
T5 768-867 Sentence denotes Surprisingly, the linear sulfated fucan was cleaved by mild acid hydrolysis on an ordered sequence.
T5 768-867 Sentence denotes Surprisingly, the linear sulfated fucan was cleaved by mild acid hydrolysis on an ordered sequence.
TextSentencer_T6 868-944 Sentence denotes Initially a 2-sulfate ester of the first fucose unit is selectively removed.
T6 868-944 Sentence denotes Initially a 2-sulfate ester of the first fucose unit is selectively removed.
T6 868-944 Sentence denotes Initially a 2-sulfate ester of the first fucose unit is selectively removed.
TextSentencer_T7 945-1150 Sentence denotes Thereafter the glycosidic linkage between the nonsulfated fucose residue and the subsequent 4-sulfated residue is preferentially cleaved by acid hydrolysis, forming oligosaccharides with well-defined size.
T7 945-1150 Sentence denotes Thereafter the glycosidic linkage between the nonsulfated fucose residue and the subsequent 4-sulfated residue is preferentially cleaved by acid hydrolysis, forming oligosaccharides with well-defined size.
T7 945-1150 Sentence denotes Thereafter the glycosidic linkage between the nonsulfated fucose residue and the subsequent 4-sulfated residue is preferentially cleaved by acid hydrolysis, forming oligosaccharides with well-defined size.
TextSentencer_T8 1151-1372 Sentence denotes The low-molecular-weight derivatives obtained from the sulfated fucan were employed to determine the requirement for interaction of this polysaccharide with heparin cofactor II and to achieve complete thrombin inhibition.
T8 1151-1372 Sentence denotes The low-molecular-weight derivatives obtained from the sulfated fucan were employed to determine the requirement for interaction of this polysaccharide with heparin cofactor II and to achieve complete thrombin inhibition.
T8 1151-1372 Sentence denotes The low-molecular-weight derivatives obtained from the sulfated fucan were employed to determine the requirement for interaction of this polysaccharide with heparin cofactor II and to achieve complete thrombin inhibition.
TextSentencer_T9 1373-1504 Sentence denotes The linear sulfated fucan requires significantly longer chains than mammalian glycosaminoglycans to achieve anticoagulant activity.
T9 1373-1504 Sentence denotes The linear sulfated fucan requires significantly longer chains than mammalian glycosaminoglycans to achieve anticoagulant activity.
T9 1373-1504 Sentence denotes The linear sulfated fucan requires significantly longer chains than mammalian glycosaminoglycans to achieve anticoagulant activity.
TextSentencer_T10 1505-1656 Sentence denotes A slight decrease in the molecular size of the sulfated fucan dramatically reduces its effect on thrombin inactivation mediated by heparin cofactor II.
T10 1505-1656 Sentence denotes A slight decrease in the molecular size of the sulfated fucan dramatically reduces its effect on thrombin inactivation mediated by heparin cofactor II.
T10 1505-1656 Sentence denotes A slight decrease in the molecular size of the sulfated fucan dramatically reduces its effect on thrombin inactivation mediated by heparin cofactor II.
TextSentencer_T11 1657-1823 Sentence denotes Sulfated fucan with approximately 45 tetrasaccharide repeating units binds to heparin cofactor II but is unable to link efficiently the plasma inhibitor and thrombin.
T11 1657-1823 Sentence denotes Sulfated fucan with approximately 45 tetrasaccharide repeating units binds to heparin cofactor II but is unable to link efficiently the plasma inhibitor and thrombin.
T11 1657-1823 Sentence denotes Sulfated fucan with approximately 45 tetrasaccharide repeating units binds to heparin cofactor II but is unable to link efficiently the plasma inhibitor and thrombin.
TextSentencer_T12 1824-1920 Sentence denotes This last effect requires chains with approximately 100 or more tetrasaccharide repeating units.
T12 1824-1920 Sentence denotes This last effect requires chains with approximately 100 or more tetrasaccharide repeating units.
T12 1824-1920 Sentence denotes This last effect requires chains with approximately 100 or more tetrasaccharide repeating units.
TextSentencer_T13 1921-2110 Sentence denotes We speculate that the template mechanism may predominate over the allosteric effect in the case of the linear sulfated fucan inactivation of thrombin in the presence of heparin cofactor II.
T13 1921-2110 Sentence denotes We speculate that the template mechanism may predominate over the allosteric effect in the case of the linear sulfated fucan inactivation of thrombin in the presence of heparin cofactor II.
T13 1921-2110 Sentence denotes We speculate that the template mechanism may predominate over the allosteric effect in the case of the linear sulfated fucan inactivation of thrombin in the presence of heparin cofactor II.