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PubMed:15537790 JSONTXT 49 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-114 Sentence denotes Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
T1 0-114 Sentence denotes Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
T1 0-114 Sentence denotes Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.
TextSentencer_T2 115-292 Sentence denotes In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD).
T2 115-292 Sentence denotes In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD).
T2 115-292 Sentence denotes In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD).
TextSentencer_T3 293-502 Sentence denotes Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal.
T3 293-502 Sentence denotes Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal.
T3 293-502 Sentence denotes Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal.
TextSentencer_T4 503-554 Sentence denotes In humans there are a total of three EDEM homologs.
T4 503-554 Sentence denotes In humans there are a total of three EDEM homologs.
T4 503-554 Sentence denotes In humans there are a total of three EDEM homologs.
TextSentencer_T5 555-708 Sentence denotes The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases).
T5 555-708 Sentence denotes The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases).
T5 555-708 Sentence denotes The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases).
TextSentencer_T6 709-822 Sentence denotes In this study, we characterize one of the EDEM homologs from Homo sapiens, which we have termed EDEM2 (C20orf31).
T6 709-822 Sentence denotes In this study, we characterize one of the EDEM homologs from Homo sapiens, which we have termed EDEM2 (C20orf31).
T6 709-822 Sentence denotes In this study, we characterize one of the EDEM homologs from Homo sapiens, which we have termed EDEM2 (C20orf31).
TextSentencer_T7 823-907 Sentence denotes Using recombinantly generated EDEM2, no alpha-1,2 mannosidase activity was observed.
T7 823-907 Sentence denotes Using recombinantly generated EDEM2, no alpha-1,2 mannosidase activity was observed.
T7 823-907 Sentence denotes Using recombinantly generated EDEM2, no alpha-1,2 mannosidase activity was observed.
TextSentencer_T8 908-1023 Sentence denotes In HEK293 cells, recombinant EDEM2 is localized to the ER where it can associate with misfolded alpha1-antitrypsin.
T8 908-1023 Sentence denotes In HEK293 cells, recombinant EDEM2 is localized to the ER where it can associate with misfolded alpha1-antitrypsin.
T8 908-1023 Sentence denotes In HEK293 cells, recombinant EDEM2 is localized to the ER where it can associate with misfolded alpha1-antitrypsin.
TextSentencer_T9 1024-1157 Sentence denotes Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.
T9 1024-1157 Sentence denotes Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.
T9 1024-1157 Sentence denotes Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.