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PubMed:15389972 JSONTXT 6 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-57 Sentence denotes Etiology of Paget's disease and osteoclast abnormalities.
T1 0-57 Sentence denotes Etiology of Paget's disease and osteoclast abnormalities.
TextSentencer_T2 58-186 Sentence denotes Paget's disease of bone is a chronic focal skeletal disorder that affects up to 2-3% of the population over the age of 60 years.
T2 58-186 Sentence denotes Paget's disease of bone is a chronic focal skeletal disorder that affects up to 2-3% of the population over the age of 60 years.
TextSentencer_T3 187-244 Sentence denotes Paget's disease is primarily a disease of the osteoclast.
T3 187-244 Sentence denotes Paget's disease is primarily a disease of the osteoclast.
TextSentencer_T4 245-424 Sentence denotes The pathologic abnormality in patients with Paget's disease involves increased bone resorption by the osteoclasts, followed by abundant new bone formation that is of poor quality.
T4 245-424 Sentence denotes The pathologic abnormality in patients with Paget's disease involves increased bone resorption by the osteoclasts, followed by abundant new bone formation that is of poor quality.
TextSentencer_T5 425-581 Sentence denotes Genetic linkage analysis indicated that 40% of patients with Paget's disease have an affected first degree relative and 1% of patients develop osteosarcoma.
T5 425-581 Sentence denotes Genetic linkage analysis indicated that 40% of patients with Paget's disease have an affected first degree relative and 1% of patients develop osteosarcoma.
TextSentencer_T6 582-656 Sentence denotes Paget's disease is an autosomal dominant trait with genetic heterogeneity.
T6 582-656 Sentence denotes Paget's disease is an autosomal dominant trait with genetic heterogeneity.
TextSentencer_T7 657-797 Sentence denotes Recurrent mutations in the ubiquitin-associated (UBA) domain of sequestosome 1 (SQSTM1/p62) are identified in patients with Paget's disease.
T7 657-797 Sentence denotes Recurrent mutations in the ubiquitin-associated (UBA) domain of sequestosome 1 (SQSTM1/p62) are identified in patients with Paget's disease.
TextSentencer_T8 798-972 Sentence denotes Osteoclasts and osteoclast precursors from patients with Paget's disease contain paramyxoviral transcripts and appear hyperresponsive to 1,25-(OH)2D3 and RANK ligand (RANKL).
T8 798-972 Sentence denotes Osteoclasts and osteoclast precursors from patients with Paget's disease contain paramyxoviral transcripts and appear hyperresponsive to 1,25-(OH)2D3 and RANK ligand (RANKL).
TextSentencer_T9 973-1164 Sentence denotes It has been suggested that the enhanced sensitivity of osteoclast precursors for 1,25-(OH)2D3 in Paget's disease results from increased expression of coactivators of vitamin D receptor (VDR).
T9 973-1164 Sentence denotes It has been suggested that the enhanced sensitivity of osteoclast precursors for 1,25-(OH)2D3 in Paget's disease results from increased expression of coactivators of vitamin D receptor (VDR).
TextSentencer_T10 1165-1338 Sentence denotes However, a cause and effect relationship for the paramyxoviral infection and SQSTM1/p62 gene mutations associated with this disease and osteoclast abnormalities are unclear.
T10 1165-1338 Sentence denotes However, a cause and effect relationship for the paramyxoviral infection and SQSTM1/p62 gene mutations associated with this disease and osteoclast abnormalities are unclear.
TextSentencer_T11 1339-1400 Sentence denotes Therefore, the etiology of Paget's disease remains uncertain.
T11 1339-1400 Sentence denotes Therefore, the etiology of Paget's disease remains uncertain.