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PubMed:15337768 JSONTXT 37 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-55 Sentence denotes The human FA2H gene encodes a fatty acid 2-hydroxylase.
T2 56-142 Sentence denotes 2-Hydroxysphingolipids are a subset of sphingolipids containing 2-hydroxy fatty acids.
T3 143-294 Sentence denotes The 2-hydroxylation occurs during de novo ceramide synthesis and is catalyzed by fatty acid 2-hydroxylase (also known as fatty acid alpha-hydroxylase).
T4 295-459 Sentence denotes In mammals, 2-hydroxysphingolipids are present abundantly in brain because the major myelin lipids galactosylceramides and sulfatides contain 2-hydroxy fatty acids.
T5 460-567 Sentence denotes Here we report identification and characterization of a human gene that encodes a fatty acid 2-hydroxylase.
T6 568-683 Sentence denotes Data base searches revealed a human homologue of the yeast ceramide 2-hydroxylase gene (FAH1), which we named FA2H.
T7 684-783 Sentence denotes The FA2H gene encodes a 372-amino acid protein with 36% identity and 46% similarity to yeast Fah1p.
T8 784-921 Sentence denotes The amino acid sequence indicates that FA2H protein contains an N-terminal cytochrome b5 domain and four potential transmembrane domains.
T9 922-1030 Sentence denotes FA2H also contains the iron-binding histidine motif conserved among membrane-bound desaturases/hydroxylases.
T10 1031-1201 Sentence denotes COS7 cells expressing human FA2H contained 3-20-fold higher levels of 2-hydroxyceramides (C16, C18, C24, and C24:1) and 2-hydroxy fatty acids compared with control cells.
T11 1202-1379 Sentence denotes Microsomal fractions prepared from transfected COS7 cells showed tetracosanoic acid 2-hydroxylase activities in an NADPH- and NADPH: cytochrome P-450 reductase-dependent manner.
T12 1380-1519 Sentence denotes FA2H lacking the N-terminal cytochrome b5 domain had little activity, indicating that this domain is a functional component of this enzyme.
T13 1520-1616 Sentence denotes Northern blot analysis showed that the FA2H gene is highly expressed in brain and colon tissues.
T14 1617-1703 Sentence denotes These results demonstrate that the human FA2H gene encodes a fatty acid 2-hydroxylase.
T15 1704-1801 Sentence denotes FA2H is likely involved in the formation of myelin 2-hydroxy galactosylceramides and -sulfatides.