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PubMed:15319452 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-98 Sentence denotes Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells.
T1 0-98 Sentence denotes Multiple kinase cascades mediate prolactin signals to activating protein-1 in breast cancer cells.
TextSentencer_T2 99-458 Sentence denotes The importance of prolactin (PRL) in physiological proliferation and differentiation of the mammary gland, together with high levels of PRL receptors in breast tumors, the association of circulating PRL with incidence of breast cancer, and the recognition of locally produced PRL, point to the need for greater understanding of PRL actions in mammary disease.
T2 99-458 Sentence denotes The importance of prolactin (PRL) in physiological proliferation and differentiation of the mammary gland, together with high levels of PRL receptors in breast tumors, the association of circulating PRL with incidence of breast cancer, and the recognition of locally produced PRL, point to the need for greater understanding of PRL actions in mammary disease.
TextSentencer_T3 459-742 Sentence denotes Although PRL has been shown to activate multiple kinase cascades in various target cells, relatively little is known of its signaling pathways in the mammary gland apart from the Janus kinase 2/ signal transducer and activator of transcription 5 pathway, particularly in tumor cells.
T3 459-742 Sentence denotes Although PRL has been shown to activate multiple kinase cascades in various target cells, relatively little is known of its signaling pathways in the mammary gland apart from the Janus kinase 2/ signal transducer and activator of transcription 5 pathway, particularly in tumor cells.
TextSentencer_T4 743-936 Sentence denotes Another potential effector is activating protein-1 (AP-1), a transcription complex that regulates processes essential for neoplastic progression, including proliferation, survival and invasion.
T4 743-936 Sentence denotes Another potential effector is activating protein-1 (AP-1), a transcription complex that regulates processes essential for neoplastic progression, including proliferation, survival and invasion.
TextSentencer_T5 937-1042 Sentence denotes We demonstrate that PRL activates AP-1 in MCF-7 cells, detectable at 4 h and sustained for at least 24 h.
T5 937-1042 Sentence denotes We demonstrate that PRL activates AP-1 in MCF-7 cells, detectable at 4 h and sustained for at least 24 h.
TextSentencer_T6 1043-1232 Sentence denotes Although Janus kinase 2 and ERK1/2 are the primary mediators of PRL-induced signals, c-Src, phosphatidylinositol 3'-kinase, protein kinase C, and other MAPKs contribute to maximal activity.
T6 1043-1232 Sentence denotes Although Janus kinase 2 and ERK1/2 are the primary mediators of PRL-induced signals, c-Src, phosphatidylinositol 3'-kinase, protein kinase C, and other MAPKs contribute to maximal activity.
TextSentencer_T7 1233-1420 Sentence denotes PRL activation of these pathways leads to increased c-Jun protein and phosphorylation, JunB protein, and phosphorylation of c-Fos, elevating the levels of AP-1 complexes able to bind DNA.
T7 1233-1420 Sentence denotes PRL activation of these pathways leads to increased c-Jun protein and phosphorylation, JunB protein, and phosphorylation of c-Fos, elevating the levels of AP-1 complexes able to bind DNA.
TextSentencer_T8 1421-1545 Sentence denotes These active AP-1 dimers may direct expression of multiple target genes, mediating some of PRL's actions in mammary disease.
T8 1421-1545 Sentence denotes These active AP-1 dimers may direct expression of multiple target genes, mediating some of PRL's actions in mammary disease.