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PubMed:15292179 / 4-1816 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T2 121-196 Sentence denotes Oxidative stress plays a major role in hyperoxia-induced acute lung injury.
T3 197-307 Sentence denotes We have shown previously that mice lacking the Nrf2 are more susceptible to hyperoxia than are wild-type mice.
T4 308-437 Sentence denotes Nrf2 activates antioxidant response element (ARE)-mediated gene expression involved in cellular protection against toxic insults.
T5 438-612 Sentence denotes The present study was designed to investigate the mechanisms that control the activation of Nrf2 by hyperoxia using a non-malignant murine alveolar epithelial cell line, C10.
T6 613-720 Sentence denotes No significant alteration in the levels of Nrf2 mRNA and protein was found following exposure to hyperoxia.
T7 721-840 Sentence denotes In contrast, hyperoxia caused the translocation of Nrf2 from the cytoplasm to the nucleus within 30-60 min of exposure.
T8 841-1049 Sentence denotes Consistent with these observations, gel shift and reporter analyses demonstrated a correlation between the hyperoxia-enhanced ARE DNA-binding activity of Nrf2 and an up-regulation of ARE-driven transcription.
T9 1050-1172 Sentence denotes Inhibition of NADPH oxidase with diphenyleneiodonium (DPI) blocked both Nrf2 translocation and ARE-mediated transcription.
T10 1173-1231 Sentence denotes Inhibition of the MEK/ERK pathway caused a similar effect.
T11 1232-1375 Sentence denotes Consistent with this finding, hyperoxia stimulated ERK-1 and ERK-2 phosphorylation, whereas DPI or N-acetyl-l-cysteine blocked such activation.
T12 1376-1542 Sentence denotes Hyperoxia stimulated the phosphorylation of endogenous Nrf2, but not in the presence of U0126, suggesting a critical role for ERK signaling in the activation of Nrf2.
T13 1543-1661 Sentence denotes Consistent with this notion, hyperoxia did not stimulate the phosphorylation of Nrf2 in fibroblasts lacking the ERK-1.