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PubMed:15271987 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes Aberrant regulation of survivin by the RB/E2F family of proteins.
T2 66-143 Sentence denotes Survivin is a putative oncogene that is aberrantly expressed in cancer cells.
T3 144-263 Sentence denotes It has been hypothesized to play a central role in cancer progression and resistance to therapy in diverse tumor types.
T4 264-512 Sentence denotes Although some of the transcriptional processes regulating its expression have been established, the diversity of genes that may be controlling the levels of its expression in both normal cells as well as in cancer cells has not been fully explored.
T5 513-640 Sentence denotes The most common genetically mutated pathways in human malignancies are the p53 tumor suppressor pathway and the RB/E2F pathway.
T6 641-786 Sentence denotes Both of these pathways, when intact, provide essential checkpoints in the maintenance of normal cell growth and protect the cell from DNA damage.
T7 787-955 Sentence denotes Using non-transformed embryonic fibroblasts, we provide evidence of a molecular link between the regulation of survivin transcription and the RB/E2F family of proteins.
T8 956-1073 Sentence denotes We demonstrate that both pRB and p130 can interact with the survivin promoter and can repress survivin transcription.
T9 1074-1202 Sentence denotes We also show that the E2F activators (E2F1, E2F2, and E2F3) can bind to the survivin promoter and induce survivin transcription.
T10 1203-1334 Sentence denotes Genetically modified cells that harbor deletions in various members of the RB/E2F family confirm our data from the wild-type cells.
T11 1335-1617 Sentence denotes Our findings implicate several members of the RB/E2F pathway in an intricate mechanism of survivin gene regulation that, when genetically altered during the process of tumorigenesis, may function within cancer cells to aberrantly alter survivin levels and enhance tumor progression.