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PubMed:15131127 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-79 Sentence denotes Galectin-12 is required for adipogenic signaling and adipocyte differentiation.
T2 80-223 Sentence denotes Galectin-12 is a member of the galectin family consisting of beta-galactoside-binding proteins with conserved carbohydrate recognition domains.
T3 224-311 Sentence denotes This protein is preferentially expressed in peripheral blood leukocytes and adipocytes.
T4 312-462 Sentence denotes We previously showed that galectin-12 is induced by cell cycle block at the G(1) phase and causes G(1) arrest when overexpressed (Yang, R.-Y., Hsu, D.
T5 463-507 Sentence denotes K., Yu, L., Ni, J., and Liu, F.-T. (2001) J.
T6 508-513 Sentence denotes Biol.
T7 514-519 Sentence denotes Chem.
T8 520-538 Sentence denotes 276, 20252-20260).
T9 539-801 Sentence denotes Here, we show that the galectin-12 gene is expressed in mouse preadipocytes and is up-regulated when preadipocytes undergo cell cycle arrest, concomitant with acquisition of the competence to undergo differentiation in response to adipogenic hormone stimulation.
T10 802-964 Sentence denotes Following a brief down-regulation 1 day after adipogenic treatment, its expression was once again markedly elevated when cells underwent terminal differentiation.
T11 965-1305 Sentence denotes Down-regulation of endogenous galectin-12 expression by RNA interference greatly reduced the expression of the adipogenic transcription factors CCAAT/enhancer-binding protein-beta and -alpha and peroxisome proliferator-activated receptor-gamma and severely suppressed adipocyte differentiation as a result of defective adipogenic signaling.
T12 1306-1483 Sentence denotes We conclude that galectin-12 is required for signal transduction that conveys hormone stimulation to the induction of adipogenic factors essential for adipocyte differentiation.
T13 1484-1573 Sentence denotes The findings suggest that galectin-12 is a major regulator of adipose tissue development.