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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background.
T1 0-113 Sentence denotes Characterization of FAMPAC, a newly identified human pancreatic carcinoma cell line with a hereditary background.
TextSentencer_T2 114-125 Sentence denotes BACKGROUND:
T2 114-125 Sentence denotes BACKGROUND:
TextSentencer_T3 126-339 Sentence denotes A novel pancreatic carcinoma cell line, FAMPAC, was identified from investigation of poorly differentiated pancreatic adenocarcinoma cells found in a patient with a familial predisposition to pancreatic carcinoma.
T3 126-339 Sentence denotes A novel pancreatic carcinoma cell line, FAMPAC, was identified from investigation of poorly differentiated pancreatic adenocarcinoma cells found in a patient with a familial predisposition to pancreatic carcinoma.
TextSentencer_T4 340-425 Sentence denotes A gene responsible for familial pancreatic carcinoma has not been identified to date.
T4 340-425 Sentence denotes A gene responsible for familial pancreatic carcinoma has not been identified to date.
TextSentencer_T5 426-434 Sentence denotes METHODS:
T5 426-434 Sentence denotes METHODS:
TextSentencer_T6 435-547 Sentence denotes The FAMPAC cell line was characterized by its morphology, growth rate, tumorigenicity, and chromosomal analysis.
T6 435-547 Sentence denotes The FAMPAC cell line was characterized by its morphology, growth rate, tumorigenicity, and chromosomal analysis.
TextSentencer_T7 548-757 Sentence denotes Three known tumor suppressor genes, p16/CDKN2, BRCA2, and p53, all of which are important in the development of pancreatic carcinoma and frequently are involved in a variety of cancer syndromes, were analyzed.
T7 548-757 Sentence denotes Three known tumor suppressor genes, p16/CDKN2, BRCA2, and p53, all of which are important in the development of pancreatic carcinoma and frequently are involved in a variety of cancer syndromes, were analyzed.
TextSentencer_T8 758-908 Sentence denotes RESULTS: FAMPAC cells grew as an adhering monolayer in culture medium supplemented with 10% fetal bovine serum and formed tumors rapidly in nude mice.
T8 758-908 Sentence denotes RESULTS: FAMPAC cells grew as an adhering monolayer in culture medium supplemented with 10% fetal bovine serum and formed tumors rapidly in nude mice.
TextSentencer_T9 909-954 Sentence denotes The doubling time ranged from 24 to 48 hours.
T9 909-954 Sentence denotes The doubling time ranged from 24 to 48 hours.
TextSentencer_T10 955-1046 Sentence denotes Karyotype analysis demonstrated the complexity of chromosomal deletions and rearrangements.
T10 955-1046 Sentence denotes Karyotype analysis demonstrated the complexity of chromosomal deletions and rearrangements.
TextSentencer_T11 1047-1170 Sentence denotes The cells were negative for ductal differentiation markers such as cytokeratin 7 and MUC1, indicating poor differentiation.
T11 1047-1170 Sentence denotes The cells were negative for ductal differentiation markers such as cytokeratin 7 and MUC1, indicating poor differentiation.
TextSentencer_T12 1171-1393 Sentence denotes Analysis of FAMPAC cells revealed overexpression of the mutated p53 gene (exon 5, codon 175: CGC --> CAC), the presence of a homozygous deletion in the p16 gene, and the presence of wild-type BRCA2 in the tested hot spots.
T12 1171-1393 Sentence denotes Analysis of FAMPAC cells revealed overexpression of the mutated p53 gene (exon 5, codon 175: CGC --> CAC), the presence of a homozygous deletion in the p16 gene, and the presence of wild-type BRCA2 in the tested hot spots.
TextSentencer_T13 1394-1406 Sentence denotes CONCLUSIONS:
T13 1394-1406 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1407-1541 Sentence denotes To the authors' knowledge, FAMPAC is the first established human pancreatic carcinoma cell line associated with a familial background.
T14 1407-1541 Sentence denotes To the authors' knowledge, FAMPAC is the first established human pancreatic carcinoma cell line associated with a familial background.
TextSentencer_T15 1542-1622 Sentence denotes FAMPAC is a tumorigenic cell line with a complex molecular pattern of mutations.
T15 1542-1622 Sentence denotes FAMPAC is a tumorigenic cell line with a complex molecular pattern of mutations.
TextSentencer_T16 1623-1772 Sentence denotes These findings may be useful in understanding the mechanisms responsible for the development of sporadic or hereditary forms of pancreatic carcinoma.
T16 1623-1772 Sentence denotes These findings may be useful in understanding the mechanisms responsible for the development of sporadic or hereditary forms of pancreatic carcinoma.