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PubMed:15061869 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-139 Sentence denotes A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction.
T1 0-139 Sentence denotes A single-nucleotide polymorphism in the human p27kip1 gene (-838C>A) affects basal promoter activity and the risk of myocardial infarction.
TextSentencer_T2 140-151 Sentence denotes BACKGROUND:
T2 140-151 Sentence denotes BACKGROUND:
TextSentencer_T3 152-301 Sentence denotes Excessive proliferation of vascular smooth muscle cells and leukocytes within the artery wall is a major event in the development of atherosclerosis.
T3 152-301 Sentence denotes Excessive proliferation of vascular smooth muscle cells and leukocytes within the artery wall is a major event in the development of atherosclerosis.
TextSentencer_T4 302-477 Sentence denotes The growth suppressor p27kip1 associates with several cyclin-dependent kinase/cyclin complexes, thereby abrogating their capacity to induce progression through the cell cycle.
T4 302-477 Sentence denotes The growth suppressor p27kip1 associates with several cyclin-dependent kinase/cyclin complexes, thereby abrogating their capacity to induce progression through the cell cycle.
TextSentencer_T5 478-558 Sentence denotes Recent studies have implicated p27kip1 in the control of neointimal hyperplasia.
T5 478-558 Sentence denotes Recent studies have implicated p27kip1 in the control of neointimal hyperplasia.
TextSentencer_T6 559-718 Sentence denotes For instance, p27kip1 ablation in apolipoprotein-E-null mice enhanced arterial cell proliferation and accelerated atherogenesis induced by dietary cholesterol.
T6 559-718 Sentence denotes For instance, p27kip1 ablation in apolipoprotein-E-null mice enhanced arterial cell proliferation and accelerated atherogenesis induced by dietary cholesterol.
TextSentencer_T7 719-880 Sentence denotes Therefore, p27kip1 is a candidate gene to modify the risk of developing atherosclerosis and associated ischaemic events (i.e., myocardial infarction and stroke).
T7 719-880 Sentence denotes Therefore, p27kip1 is a candidate gene to modify the risk of developing atherosclerosis and associated ischaemic events (i.e., myocardial infarction and stroke).
TextSentencer_T8 881-889 Sentence denotes RESULTS:
T8 881-889 Sentence denotes RESULTS:
TextSentencer_T9 890-1023 Sentence denotes In this study we found three common single-nucleotide polymorphisms in the human p27kip1 gene (+326T>G [V109G], -79C>T, and -838C>A).
T9 890-1023 Sentence denotes In this study we found three common single-nucleotide polymorphisms in the human p27kip1 gene (+326T>G [V109G], -79C>T, and -838C>A).
TextSentencer_T10 1024-1217 Sentence denotes The frequency of -838A carriers was significantly increased in myocardial infarction patients compared to healthy controls (odds ratio [OR] = 1.73, 95% confidence interval [95%CI] = 1.12-2.70).
T10 1024-1217 Sentence denotes The frequency of -838A carriers was significantly increased in myocardial infarction patients compared to healthy controls (odds ratio [OR] = 1.73, 95% confidence interval [95%CI] = 1.12-2.70).
TextSentencer_T11 1218-1479 Sentence denotes In addition, luciferase reporter constructs driven by the human p27kip1 gene promoter containing A at position -838 had decreased basal transcriptional activity when transiently transfected in Jurkat cells, compared with constructs bearing C in -838 (P = 0.04).
T11 1218-1479 Sentence denotes In addition, luciferase reporter constructs driven by the human p27kip1 gene promoter containing A at position -838 had decreased basal transcriptional activity when transiently transfected in Jurkat cells, compared with constructs bearing C in -838 (P = 0.04).
TextSentencer_T12 1480-1492 Sentence denotes CONCLUSIONS:
T12 1480-1492 Sentence denotes CONCLUSIONS:
TextSentencer_T13 1493-1620 Sentence denotes These data suggest that -838A is associated with reduced p27kip1 promoter activity and increased risk of myocardial infarction.
T13 1493-1620 Sentence denotes These data suggest that -838A is associated with reduced p27kip1 promoter activity and increased risk of myocardial infarction.