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PubMed:15042566 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-89 Sentence denotes DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
T1 0-89 Sentence denotes DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
TextSentencer_T2 90-101 Sentence denotes BACKGROUND:
T2 90-101 Sentence denotes BACKGROUND:
TextSentencer_T3 102-250 Sentence denotes Aristolochic acid-associated nephropathy (AAN) is a specific type of renal disease that predisposes patients to a high risk of urothelial carcinoma.
T3 102-250 Sentence denotes Aristolochic acid-associated nephropathy (AAN) is a specific type of renal disease that predisposes patients to a high risk of urothelial carcinoma.
TextSentencer_T4 251-424 Sentence denotes The authors have analyzed DNA from a patient who had urothelial malignancy 6 years after presenting with AAN and later had a breast carcinoma that metastasized to the liver.
T4 251-424 Sentence denotes The authors have analyzed DNA from a patient who had urothelial malignancy 6 years after presenting with AAN and later had a breast carcinoma that metastasized to the liver.
TextSentencer_T5 425-631 Sentence denotes METHODS AND RESULTS: DNA was isolated from the primary breast tumor, the liver tumor, and the original urothelial malignancy and assayed for aristolochic acid (AA)-DNA adducts and mutations in the p53 gene.
T5 425-631 Sentence denotes METHODS AND RESULTS: DNA was isolated from the primary breast tumor, the liver tumor, and the original urothelial malignancy and assayed for aristolochic acid (AA)-DNA adducts and mutations in the p53 gene.
TextSentencer_T6 632-747 Sentence denotes The adduct detected was the adenosine adduct of aristolochic acid I 7-(deoxyadenosin-N6-yl)aristolactam I (dA-AAI).
T6 632-747 Sentence denotes The adduct detected was the adenosine adduct of aristolochic acid I 7-(deoxyadenosin-N6-yl)aristolactam I (dA-AAI).
TextSentencer_T7 748-887 Sentence denotes In DNA from the breast and liver tumors the authors showed the same missense mutation in codon 245 (GGC-->GAC; Gly-->Asp) of exon 7 of p53.
T7 748-887 Sentence denotes In DNA from the breast and liver tumors the authors showed the same missense mutation in codon 245 (GGC-->GAC; Gly-->Asp) of exon 7 of p53.
TextSentencer_T8 888-1007 Sentence denotes In contrast, DNA extracted from the urothelial tumor showed an AAG to TAG mutation in codon 139 (Lys-->Stop) of exon 5.
T8 888-1007 Sentence denotes In contrast, DNA extracted from the urothelial tumor showed an AAG to TAG mutation in codon 139 (Lys-->Stop) of exon 5.
TextSentencer_T9 1008-1019 Sentence denotes CONCLUSION:
T9 1008-1019 Sentence denotes CONCLUSION:
TextSentencer_T10 1020-1227 Sentence denotes A to T transversions, as observed here, are the typical mutations observed in the H-ras gene of tumors induced when rodents are treated with AA and correspond with DNA adduct formation at adenosine residues.
T10 1020-1227 Sentence denotes A to T transversions, as observed here, are the typical mutations observed in the H-ras gene of tumors induced when rodents are treated with AA and correspond with DNA adduct formation at adenosine residues.
TextSentencer_T11 1228-1321 Sentence denotes These data indicate the probable molecular mechanism whereby AA causes urothelial malignancy.
T11 1228-1321 Sentence denotes These data indicate the probable molecular mechanism whereby AA causes urothelial malignancy.