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PubMed:15014027 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-110 Sentence denotes Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stage.
T1 0-110 Sentence denotes Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stage.
TextSentencer_T2 111-119 Sentence denotes PURPOSE:
T2 111-119 Sentence denotes PURPOSE:
TextSentencer_T3 120-421 Sentence denotes Although the decreased expression of p27(kip-1), a cyclin-dependent kinase inhibitor, has been correlated with advanced tumor stage and short survival of patients with colorectal adenocarcinomas (CRCs), its prognostic value based on the tumor site, tumor stage, and patient ethnicity was not assessed.
T3 120-421 Sentence denotes Although the decreased expression of p27(kip-1), a cyclin-dependent kinase inhibitor, has been correlated with advanced tumor stage and short survival of patients with colorectal adenocarcinomas (CRCs), its prognostic value based on the tumor site, tumor stage, and patient ethnicity was not assessed.
TextSentencer_T4 422-580 Sentence denotes Therefore, in this study, we investigated whether the prognostic value of p27(kip-1) expression varies with the tumor site, tumor stage and patient ethnicity.
T4 422-580 Sentence denotes Therefore, in this study, we investigated whether the prognostic value of p27(kip-1) expression varies with the tumor site, tumor stage and patient ethnicity.
TextSentencer_T5 581-601 Sentence denotes EXPERIMENTAL DESIGN:
T5 581-601 Sentence denotes EXPERIMENTAL DESIGN:
TextSentencer_T6 602-883 Sentence denotes We evaluated 206 (85 African Americans and 121 Caucasians) archival tissue specimens of first primary CRCs for immunohistochemical expression of p27(kip-1), and its prognostic significance was analyzed using univariate Kaplan-Meier and multivariate Cox regression survival methods.
T6 602-883 Sentence denotes We evaluated 206 (85 African Americans and 121 Caucasians) archival tissue specimens of first primary CRCs for immunohistochemical expression of p27(kip-1), and its prognostic significance was analyzed using univariate Kaplan-Meier and multivariate Cox regression survival methods.
TextSentencer_T7 884-892 Sentence denotes RESULTS:
T7 884-892 Sentence denotes RESULTS:
TextSentencer_T8 893-1279 Sentence denotes Although, similar proportion of CRCs with decreased p27(kip-1) expression was observed in all stages (range, 26-36%), the decreased p27(kip-1) expression has been shown as a marker of poor prognosis only for patients with stage III tumors both in univariate (log-rank test, P = 0.014) and multivariate (hazard ratio = 3.2, 95% confidence interval = 1.3-7.7; P = 0.01) survival analyses.
T8 893-1279 Sentence denotes Although, similar proportion of CRCs with decreased p27(kip-1) expression was observed in all stages (range, 26-36%), the decreased p27(kip-1) expression has been shown as a marker of poor prognosis only for patients with stage III tumors both in univariate (log-rank test, P = 0.014) and multivariate (hazard ratio = 3.2, 95% confidence interval = 1.3-7.7; P = 0.01) survival analyses.
TextSentencer_T9 1280-1513 Sentence denotes The decreased expression of p27(kip-1) was associated with a high histologic grade (P = 0.016) in stage II CRCs, and with distal tumors (P = 0.001), tumor invasion (P = 0.044), and with local recurrence (P = 0.008) in stage III CRCs.
T9 1280-1513 Sentence denotes The decreased expression of p27(kip-1) was associated with a high histologic grade (P = 0.016) in stage II CRCs, and with distal tumors (P = 0.001), tumor invasion (P = 0.044), and with local recurrence (P = 0.008) in stage III CRCs.
TextSentencer_T10 1514-1526 Sentence denotes CONCLUSIONS:
T10 1514-1526 Sentence denotes CONCLUSIONS:
TextSentencer_T11 1527-1703 Sentence denotes No prognostic significance was found for p27(kip-1) expression in stages I, II, or IV CRCs, and its prognostic value was not associated with either ethnicity or tumor location.
T11 1527-1703 Sentence denotes No prognostic significance was found for p27(kip-1) expression in stages I, II, or IV CRCs, and its prognostic value was not associated with either ethnicity or tumor location.
TextSentencer_T12 1704-1885 Sentence denotes These studies suggest that decreased expression of p27(kip-1) is an indicator of poor prognosis and aids in identifying a subset of patients with aggressive forms of stage III CRCs.
T12 1704-1885 Sentence denotes These studies suggest that decreased expression of p27(kip-1) is an indicator of poor prognosis and aids in identifying a subset of patients with aggressive forms of stage III CRCs.