| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-195 |
Sentence |
denotes |
Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. |
| T2 |
196-493 |
Sentence |
denotes |
We employed a genetic approach to determine whether deficiency of 1,25-dihydroxyvitamin D (1,25(OH)2D) and deficiency of the vitamin D receptor (VDR) produce the same alterations in skeletal and calcium homeostasis and whether calcium can subserve the skeletal functions of 1,25(OH)2D and the VDR. |
| T3 |
494-908 |
Sentence |
denotes |
Mice with targeted deletion of the 25-hydroxyvitamin D 1alpha-hydroxylase (1alpha(OH)ase-/-) gene, the VDR gene, and both genes were exposed to 1) a high calcium intake, which maintained fertility but left mice hypocalcemic; 2) this intake plus three times weekly injections of 1,25(OH)2D3, which normalized calcium in the 1alpha(OH)ase-/- mice only; or 3) a "rescue" diet, which normalized calcium in all mutants. |
| T4 |
909-1038 |
Sentence |
denotes |
These regimens induced different phenotypic changes, thereby disclosing selective modulation by calcium and the vitamin D system. |
| T5 |
1039-1193 |
Sentence |
denotes |
Parathyroid gland size and the development of the cartilaginous growth plate were each regulated by calcium and by 1,25(OH)2D3 but independent of the VDR. |
| T6 |
1194-1322 |
Sentence |
denotes |
Parathyroid hormone secretion and mineralization of bone reflected ambient calcium levels rather than the 1,25(OH)2D/VDR system. |
| T7 |
1323-1463 |
Sentence |
denotes |
In contrast, increased calcium absorption and optimal osteoblastogenesis and osteoclastogenesis were modulated by the 1,25(OH)2D/VDR system. |
| T8 |
1464-1644 |
Sentence |
denotes |
These studies indicate that the calcium ion and the 1,25(OH)2D/VDR system exert discrete effects on skeletal and calcium homeostasis, which may occur coordinately or independently. |
