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PubMed:14730479 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-67 Sentence denotes Are variants in the CAPN10 gene related to risk of type 2 diabetes?
T1 0-67 Sentence denotes Are variants in the CAPN10 gene related to risk of type 2 diabetes?
TextSentencer_T2 68-145 Sentence denotes A quantitative assessment of population and family-based association studies.
T2 68-145 Sentence denotes A quantitative assessment of population and family-based association studies.
TextSentencer_T3 146-313 Sentence denotes The calpain-10 gene (CAPN10) on chromosome 2q37.3 was the first candidate gene for type 2 diabetes (T2D) identified through a genomewide screen and positional cloning.
T3 146-313 Sentence denotes The calpain-10 gene (CAPN10) on chromosome 2q37.3 was the first candidate gene for type 2 diabetes (T2D) identified through a genomewide screen and positional cloning.
TextSentencer_T4 314-505 Sentence denotes One polymorphism (UCSNP-43: G-->A) and a specific haplotype combination defined by three polymorphisms (UCSNP-43, -19, and -63) were linked to an increased risk of T2D in several populations.
T4 314-505 Sentence denotes One polymorphism (UCSNP-43: G-->A) and a specific haplotype combination defined by three polymorphisms (UCSNP-43, -19, and -63) were linked to an increased risk of T2D in several populations.
TextSentencer_T5 506-688 Sentence denotes To quantitatively assess the collective evidence for the effects of CAPN10 on risk of T2D, we conducted a meta-analysis of both population-based and family-based association studies.
T5 506-688 Sentence denotes To quantitatively assess the collective evidence for the effects of CAPN10 on risk of T2D, we conducted a meta-analysis of both population-based and family-based association studies.
TextSentencer_T6 689-863 Sentence denotes We retrieved data from the MEDLINE, PubMed, and Online Mendelian Inheritance in Man databases, as well as from other relevant reports and abstracts published up to July 2003.
T6 689-863 Sentence denotes We retrieved data from the MEDLINE, PubMed, and Online Mendelian Inheritance in Man databases, as well as from other relevant reports and abstracts published up to July 2003.
TextSentencer_T7 864-938 Sentence denotes From a total of 26 studies with primary data (21 population-based studies:
T7 864-938 Sentence denotes From a total of 26 studies with primary data (21 population-based studies:
TextSentencer_T8 939-994 Sentence denotes 5,013 cases and 5,876 controls; 5 family-based studies:
T8 939-994 Sentence denotes 5,013 cases and 5,876 controls; 5 family-based studies:
TextSentencer_T9 995-1228 Sentence denotes 487 parent-offspring trios), we developed a summary database that contains variables of study design, study population/ethnicity, specific polymorphisms and haplotype combinations in CAPN10, and diabetes-related metabolic phenotypes.
T9 995-1228 Sentence denotes 487 parent-offspring trios), we developed a summary database that contains variables of study design, study population/ethnicity, specific polymorphisms and haplotype combinations in CAPN10, and diabetes-related metabolic phenotypes.
TextSentencer_T10 1229-1447 Sentence denotes For population-based studies, we used both fixed-effects and random-effects models to calculate the pooled odds ratio (OR) and 95% confidence interval (CI) for the associations of CAPN10 genotypes with the risk of T2D.
T10 1229-1447 Sentence denotes For population-based studies, we used both fixed-effects and random-effects models to calculate the pooled odds ratio (OR) and 95% confidence interval (CI) for the associations of CAPN10 genotypes with the risk of T2D.
TextSentencer_T11 1448-1570 Sentence denotes We also calculated weighted mean differences for the associations between CAPN10 and diabetes-related quantitative traits.
T11 1448-1570 Sentence denotes We also calculated weighted mean differences for the associations between CAPN10 and diabetes-related quantitative traits.
TextSentencer_T12 1571-1731 Sentence denotes Under either an additive or a dominant effect model, we found no statistically significant relation between CAPN10 genotypes in the UCSNP-43 locus and T2D risk.
T12 1571-1731 Sentence denotes Under either an additive or a dominant effect model, we found no statistically significant relation between CAPN10 genotypes in the UCSNP-43 locus and T2D risk.
TextSentencer_T13 1732-1926 Sentence denotes However, under a recessive model, individuals homozygous for the common G allele had a statistically significant 19% higher risk of T2D than carriers of the A allele (OR 1.19; 95% CI 1.07-1.33).
T13 1732-1926 Sentence denotes However, under a recessive model, individuals homozygous for the common G allele had a statistically significant 19% higher risk of T2D than carriers of the A allele (OR 1.19; 95% CI 1.07-1.33).
TextSentencer_T14 1927-2111 Sentence denotes The association between the 112/121 haplotype combination and T2D risk appeared to be overestimated by several initial small studies with positive findings (OR 1.38; 95% CI 1.04-1.84).
T14 1927-2111 Sentence denotes The association between the 112/121 haplotype combination and T2D risk appeared to be overestimated by several initial small studies with positive findings (OR 1.38; 95% CI 1.04-1.84).
TextSentencer_T15 2112-2219 Sentence denotes After we removed these initial studies, this association became nonsignificant (OR 1.11; 95% CI 0.91-1.35).
T15 2112-2219 Sentence denotes After we removed these initial studies, this association became nonsignificant (OR 1.11; 95% CI 0.91-1.35).
TextSentencer_T16 2220-2369 Sentence denotes Moreover, we found no evidence for the associations between the UCSNP-43 G/G genotype and the 112/121 haplotype combination and metabolic phenotypes.
T16 2220-2369 Sentence denotes Moreover, we found no evidence for the associations between the UCSNP-43 G/G genotype and the 112/121 haplotype combination and metabolic phenotypes.
TextSentencer_T17 2370-2540 Sentence denotes Our meta-analysis of family-based studies showed only an overtransmission of the rare allele C in UCSNP-44 from heterozygous parents to their affected offspring with T2D.
T17 2370-2540 Sentence denotes Our meta-analysis of family-based studies showed only an overtransmission of the rare allele C in UCSNP-44 from heterozygous parents to their affected offspring with T2D.
TextSentencer_T18 2541-2881 Sentence denotes Our analysis indicates that inadequate statistical power, racial/ethnic differences in frequencies of alleles, haplotypes and haplotype combinations, potential gene-gene or gene-environment interactions, publication bias, and multiple hypothesis testing may contribute to the significant heterogeneity in previous studies of CAPN10 and T2D.
T18 2541-2881 Sentence denotes Our analysis indicates that inadequate statistical power, racial/ethnic differences in frequencies of alleles, haplotypes and haplotype combinations, potential gene-gene or gene-environment interactions, publication bias, and multiple hypothesis testing may contribute to the significant heterogeneity in previous studies of CAPN10 and T2D.
TextSentencer_T19 2882-3116 Sentence denotes Our findings also suggest that both large-scale, well-designed association studies and functional studies are warranted to either reliably confirm or conclusively refute the initial hypothesis regarding the role of CAPN10 in T2D risk.
T19 2882-3116 Sentence denotes Our findings also suggest that both large-scale, well-designed association studies and functional studies are warranted to either reliably confirm or conclusively refute the initial hypothesis regarding the role of CAPN10 in T2D risk.