| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-171 |
Sentence |
denotes |
Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node. |
| T2 |
172-450 |
Sentence |
denotes |
A new C-type lectin-like gene encodes 293 amino acids and maps to chromosome 19p13.3 adjacent to the previously described C-type lectin genes, CD23, dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), and DC-SIGN-related protein (DC-SIGNR). |
| T3 |
451-553 |
Sentence |
denotes |
The four genes form a tight cluster in an insert size of 105 kb and have analogous genomic structures. |
| T4 |
554-860 |
Sentence |
denotes |
The new C-type lectin-like molecule, designated liver and lymph node sinusoidal endothelial cell C-type lectin (LSECtin), is a type II integral membrane protein of approximately 40 kDa in size with a single C-type lectin-like domain at the COOH terminus, closest in homology to DC-SIGNR, DC-SIGN, and CD23. |
| T5 |
861-1053 |
Sentence |
denotes |
LSECtin mRNA was only expressed in liver and lymph node among 15 human tissues tested, intriguingly neither expressed on hematopoietic cell lines nor on monocyte-derived dendritic cells (DCs). |
| T6 |
1054-1192 |
Sentence |
denotes |
Moreover, LSECtin is expressed predominantly by sinusoidal endothelial cells of human liver and lymph node and co-expressed with DC-SIGNR. |
| T7 |
1193-1288 |
Sentence |
denotes |
LSECtin binds to mannose, GlcNAc, and fucose in a Ca(2+)-dependent manner but not to galactose. |
| T8 |
1289-1452 |
Sentence |
denotes |
Our results indicate that LSECtin is a novel member of a family of proteins comprising CD23, DC-SIGN, and DC-SIGNR and might function in vivo as a lectin receptor. |
