| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-103 |
Sentence |
denotes |
Sulfatide is associated with insulin granules and located to microdomains of a cultured beta cell line. |
| T1 |
0-103 |
Sentence |
denotes |
Sulfatide is associated with insulin granules and located to microdomains of a cultured beta cell line. |
| TextSentencer_T2 |
104-329 |
Sentence |
denotes |
Previous studies using pancreas from various mammals and freshly isolated islets from rat pancreas have provided evidence supporting possible involvement of the glycosphingolipid sulfatide in insulin processing and secretion. |
| T2 |
104-329 |
Sentence |
denotes |
Previous studies using pancreas from various mammals and freshly isolated islets from rat pancreas have provided evidence supporting possible involvement of the glycosphingolipid sulfatide in insulin processing and secretion. |
| TextSentencer_T3 |
330-567 |
Sentence |
denotes |
In this study, sulfatide expression and metabolism in the beta cell line RINr1046-38 (RIN-38), commonly used as a model for beta cell functional studies, were investigated and compared with previous findings from freshly isolated islets. |
| T3 |
330-567 |
Sentence |
denotes |
In this study, sulfatide expression and metabolism in the beta cell line RINr1046-38 (RIN-38), commonly used as a model for beta cell functional studies, were investigated and compared with previous findings from freshly isolated islets. |
| TextSentencer_T4 |
568-752 |
Sentence |
denotes |
RIN-38 cells expressed similar amounts (2.7 +/- 1.1 nmol/mg protein, n = 19) of sulfatide as isolated rat islets and also followed the same metabolic pathway, mainly through recycling. |
| T4 |
568-752 |
Sentence |
denotes |
RIN-38 cells expressed similar amounts (2.7 +/- 1.1 nmol/mg protein, n = 19) of sulfatide as isolated rat islets and also followed the same metabolic pathway, mainly through recycling. |
| TextSentencer_T5 |
753-906 |
Sentence |
denotes |
Moreover, in agreement with findings in isolated islets, the major species of sulfatide isolated from RIN-38 cells contained C16:0 and C24:0 fatty acids. |
| T5 |
753-906 |
Sentence |
denotes |
Moreover, in agreement with findings in isolated islets, the major species of sulfatide isolated from RIN-38 cells contained C16:0 and C24:0 fatty acids. |
| TextSentencer_T6 |
907-1132 |
Sentence |
denotes |
By applying subcellular isolations and electron microscopy and immunocytochemistry techniques, sulfatide was shown to be located to the secretory granules, the plasma membrane and enriched in detergent insoluble microdomains. |
| T6 |
907-1132 |
Sentence |
denotes |
By applying subcellular isolations and electron microscopy and immunocytochemistry techniques, sulfatide was shown to be located to the secretory granules, the plasma membrane and enriched in detergent insoluble microdomains. |
| TextSentencer_T7 |
1133-1245 |
Sentence |
denotes |
In the electron microscopy studies, Sulph I staining was also associated with mitochondria and villi structures. |
| T7 |
1133-1245 |
Sentence |
denotes |
In the electron microscopy studies, Sulph I staining was also associated with mitochondria and villi structures. |
| TextSentencer_T8 |
1246-1499 |
Sentence |
denotes |
In conclusion, RIN-38 cells might be an appropriate model, as a complement to isolated islets where the amount of material often limits the experiments, to further explore the role of sulfatide in insulin secretion and signal transduction of beta cells. |
| T8 |
1246-1499 |
Sentence |
denotes |
In conclusion, RIN-38 cells might be an appropriate model, as a complement to isolated islets where the amount of material often limits the experiments, to further explore the role of sulfatide in insulin secretion and signal transduction of beta cells. |
