| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-149 |
Sentence |
denotes |
p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I. |
| T2 |
150-298 |
Sentence |
denotes |
p8 is a transcription cofactor whose expression is strongly and rapidly activated in pancreatic acinar cells during the acute phase of pancreatitis. |
| T3 |
299-379 |
Sentence |
denotes |
A p8-deficient mouse strain was generated as a tool to investigate its function. |
| T4 |
380-683 |
Sentence |
denotes |
Upon induction of acute pancreatitis, myeloperoxidase activity in pancreas and serum concentrations of amylase and lipase were much higher and pancreatic lesions more severe in p8-deficient mice than in wild-type, indicating that p8 expression decreased pancreatic sensitivity to pancreatitis induction. |
| T5 |
684-938 |
Sentence |
denotes |
The protective mechanism might involve the pancreatitis-associated protein (PAP I), whose strong induction during pancreatitis is p8-dependent, because administration of anti-PAP I antibodies to rats increased pancreatic inflammation during pancreatitis. |
| T6 |
939-1127 |
Sentence |
denotes |
In addition, 100 ng/ml PAP I in the culture medium of macrophages prevented their activation by tumor necrosis factor alpha, strongly suggesting that PAP I was an anti-inflammatory factor. |
| T7 |
1128-1275 |
Sentence |
denotes |
Finally, PAP I was able to inhibit NFkappaB activation by tumor necrosis factor alpha, in macrophages and in the AR42J pancreatic acinar cell line. |
| T8 |
1276-1440 |
Sentence |
denotes |
In conclusion, p8 improves pancreatic resistance to inducers of acute pancreatitis by a mechanism implicating the expression of the anti-inflammatory protein PAP I. |
