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PubMed:14627671 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-115 Sentence denotes Analysis of the Birt-Hogg-Dubé (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer.
T1 0-115 Sentence denotes Analysis of the Birt-Hogg-Dubé (BHD) tumour suppressor gene in sporadic renal cell carcinoma and colorectal cancer.
TextSentencer_T2 116-244 Sentence denotes Germline mutations in the BHD gene cause the dominantly inherited cancer susceptibility disorder, Birt-Hogg-Dubé (BHD) syndrome.
T2 116-244 Sentence denotes Germline mutations in the BHD gene cause the dominantly inherited cancer susceptibility disorder, Birt-Hogg-Dubé (BHD) syndrome.
TextSentencer_T3 245-371 Sentence denotes Individuals with BHD are reported to have an increased risk of renal cell carcinoma (RCC) and of colorectal polyps and cancer.
T3 245-371 Sentence denotes Individuals with BHD are reported to have an increased risk of renal cell carcinoma (RCC) and of colorectal polyps and cancer.
TextSentencer_T4 372-652 Sentence denotes The BHD gene maps to 17p11.2, and to investigate whether somatic inactivation of the BHD gene region is implicated in the pathogenesis of sporadic RCC and colorectal cancer (CRC), we performed mutation analysis in 30 RCC primary tumours and cell lines, and 35 CRCs and cell lines.
T4 372-652 Sentence denotes The BHD gene maps to 17p11.2, and to investigate whether somatic inactivation of the BHD gene region is implicated in the pathogenesis of sporadic RCC and colorectal cancer (CRC), we performed mutation analysis in 30 RCC primary tumours and cell lines, and 35 CRCs and cell lines.
TextSentencer_T5 653-960 Sentence denotes A somatic missense mutation (Ala444Ser) with loss of the wild type allele (consistent with a two hit mechanism of tumorigenesis) was detected in a primary clear cell RCC, and a further missense mutation (Ala238Val) was identified in a clear cell RCC cell line for which matched normal DNA was not available.
T5 653-960 Sentence denotes A somatic missense mutation (Ala444Ser) with loss of the wild type allele (consistent with a two hit mechanism of tumorigenesis) was detected in a primary clear cell RCC, and a further missense mutation (Ala238Val) was identified in a clear cell RCC cell line for which matched normal DNA was not available.
TextSentencer_T6 961-1150 Sentence denotes A somatic missense substitution (Arg392Gly) was identified in a primary CRC, and the same change was detected in three RCCs (all oncocytomas) for which matched normal DNA was not available.
T6 961-1150 Sentence denotes A somatic missense substitution (Arg392Gly) was identified in a primary CRC, and the same change was detected in three RCCs (all oncocytomas) for which matched normal DNA was not available.
TextSentencer_T7 1151-1310 Sentence denotes A germline Arg320Gln missense variant detected in a primary CRC was not detected in 40 control individuals or in a further 159 familial and sporadic CRC cases.
T7 1151-1310 Sentence denotes A germline Arg320Gln missense variant detected in a primary CRC was not detected in 40 control individuals or in a further 159 familial and sporadic CRC cases.
TextSentencer_T8 1311-1474 Sentence denotes However, AA homozygotes for an intronic single nucleotide polymorphism (c.1517+6 G-->A) were under-represented in familial cases compared with controls (p = 0.03).
T8 1311-1474 Sentence denotes However, AA homozygotes for an intronic single nucleotide polymorphism (c.1517+6 G-->A) were under-represented in familial cases compared with controls (p = 0.03).
TextSentencer_T9 1475-1596 Sentence denotes For some tumour suppressor genes, epigenetic silencing is a more common mechanism of inactivation than somatic mutations.
T9 1475-1596 Sentence denotes For some tumour suppressor genes, epigenetic silencing is a more common mechanism of inactivation than somatic mutations.
TextSentencer_T10 1597-1771 Sentence denotes However, we did not detect evidence of epigenetic silencing of BHD in 19 CRC and RCC cell lines, and BHD promoter region hypermethylation was not detected in 20 primary RCCs.
T10 1597-1771 Sentence denotes However, we did not detect evidence of epigenetic silencing of BHD in 19 CRC and RCC cell lines, and BHD promoter region hypermethylation was not detected in 20 primary RCCs.
TextSentencer_T11 1772-1862 Sentence denotes These findings suggest that BHD inactivation occurs in a subset of clear cell RCC and CRC.
T11 1772-1862 Sentence denotes These findings suggest that BHD inactivation occurs in a subset of clear cell RCC and CRC.