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Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes Sphingolipids are essential for the growth of Chinese hamster ovary cells.
T1 0-74 Sentence denotes Sphingolipids are essential for the growth of Chinese hamster ovary cells.
T2 75-181 Sentence denotes Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids.
T2 75-181 Sentence denotes Restoration of the growth of a mutant defective in sphingoid base biosynthesis by exogenous sphingolipids.
T3 182-441 Sentence denotes We previously isolated a temperature-sensitive Chinese hamster ovary cell mutant (strain SPB-1) with thermolabile serine palmitoyltransferase, which is involved in the first step of sphingolipid synthesis (Hanada, K., Nishijima, M., and Akamatsu, Y. (1990) J.
T3 182-441 Sentence denotes We previously isolated a temperature-sensitive Chinese hamster ovary cell mutant (strain SPB-1) with thermolabile serine palmitoyltransferase, which is involved in the first step of sphingolipid synthesis (Hanada, K., Nishijima, M., and Akamatsu, Y. (1990) J.
T4 442-447 Sentence denotes Biol.
T4 442-447 Sentence denotes Biol.
T5 448-453 Sentence denotes Chem.
T5 448-453 Sentence denotes Chem.
T6 454-472 Sentence denotes 265, 22137-22142).
T6 454-472 Sentence denotes 265, 22137-22142).
T7 473-612 Sentence denotes In this study, sphingolipid-deficient culture medium was used to examine the effect of exogenous sphingolipids on the cell growth of SPB-1.
T7 473-612 Sentence denotes In this study, sphingolipid-deficient culture medium was used to examine the effect of exogenous sphingolipids on the cell growth of SPB-1.
T8 613-725 Sentence denotes When cultivated in the sphingolipid-deficient medium, SPB-1 cells ceased growing at non-permissive temperatures.
T8 613-725 Sentence denotes When cultivated in the sphingolipid-deficient medium, SPB-1 cells ceased growing at non-permissive temperatures.
T9 726-996 Sentence denotes Under these conditions, de novo sphingolipid synthesis ceased in the SPB-1 cells, resulting in a decrease in levels of sphingomyelin and ganglioside sialyl lactosylceramide (GM3), whereas the parental CHO-K1 cells grew logarithmically with normal sphingolipid synthesis.
T9 726-996 Sentence denotes Under these conditions, de novo sphingolipid synthesis ceased in the SPB-1 cells, resulting in a decrease in levels of sphingomyelin and ganglioside sialyl lactosylceramide (GM3), whereas the parental CHO-K1 cells grew logarithmically with normal sphingolipid synthesis.
T10 997-1224 Sentence denotes Exogenous sphingosine restored the contents of both sphingomyelin and GM3 in the SPB-1 cells near to the parental levels through metabolic utilization and allowed the mutant cells to grow even at the non-permissive temperature.
T10 997-1224 Sentence denotes Exogenous sphingosine restored the contents of both sphingomyelin and GM3 in the SPB-1 cells near to the parental levels through metabolic utilization and allowed the mutant cells to grow even at the non-permissive temperature.
T11 1225-1398 Sentence denotes Similarly, exogenous sphingomyelin restored the sphingomyelin levels and only partly the GM3 levels and also suppressed the temperature-sensitivity of the SPB-1 cell growth.
T11 1225-1398 Sentence denotes Similarly, exogenous sphingomyelin restored the sphingomyelin levels and only partly the GM3 levels and also suppressed the temperature-sensitivity of the SPB-1 cell growth.
T12 1399-1576 Sentence denotes In contrast, exogenous glucosylceramide, which restored the GM3 levels but not the sphingomyelin levels, failed to suppress the temperature sensitivity of the SPB-1 cell growth.
T12 1399-1576 Sentence denotes In contrast, exogenous glucosylceramide, which restored the GM3 levels but not the sphingomyelin levels, failed to suppress the temperature sensitivity of the SPB-1 cell growth.
T13 1577-1793 Sentence denotes Combination of exogenous sphingomyelin with ceramide, glucosylceramide, GM3, or sphingoid bases did not show any synergistic or additive effect on the SPB-1 cell growth enhancement, compared with sphingomyelin alone.
T13 1577-1793 Sentence denotes Combination of exogenous sphingomyelin with ceramide, glucosylceramide, GM3, or sphingoid bases did not show any synergistic or additive effect on the SPB-1 cell growth enhancement, compared with sphingomyelin alone.
T14 1794-1952 Sentence denotes The results indicated that the temperature sensitivity of the SPB-1 cell growth was due to the lack of cellular sphingolipids, possibly that of sphingomyelin.
T14 1794-1952 Sentence denotes The results indicated that the temperature sensitivity of the SPB-1 cell growth was due to the lack of cellular sphingolipids, possibly that of sphingomyelin.