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PubMed:1429602 JSONTXT 31 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-104 Sentence denotes An amino acid substitution (Gly853-->Glu) in the collagen alpha 1(II) chain produces hypochondrogenesis.
T1 0-104 Sentence denotes An amino acid substitution (Gly853-->Glu) in the collagen alpha 1(II) chain produces hypochondrogenesis.
TextSentencer_T2 105-264 Sentence denotes The spondyloepiphyseal dysplasia subclassification of bone dysplasias includes achondrogenesis, hypochondrogenesis, and spondyloepiphyseal dysplasia congenita.
T2 105-264 Sentence denotes The spondyloepiphyseal dysplasia subclassification of bone dysplasias includes achondrogenesis, hypochondrogenesis, and spondyloepiphyseal dysplasia congenita.
TextSentencer_T3 265-353 Sentence denotes The phenotypic expression of these disorders ranges from mild to perinatal lethal forms.
T3 265-353 Sentence denotes The phenotypic expression of these disorders ranges from mild to perinatal lethal forms.
TextSentencer_T4 354-488 Sentence denotes We report the detection and partial characterization of a defect in type II collagen in a perinatal lethal form of hypochondrogenesis.
T4 354-488 Sentence denotes We report the detection and partial characterization of a defect in type II collagen in a perinatal lethal form of hypochondrogenesis.
TextSentencer_T5 489-839 Sentence denotes Electrophoresis in sodium dodecyl sulfate-polyacrylamide of CB peptides (where CB represents cyanogen bromide) from type II collagen of the diseased cartilage showed a doublet band for peptide alpha 1(II)CB10 and evidence for post-translational overmodification of the major peptides (CB8, CB10, and CB11) seen as a retarded electrophoretic mobility.
T5 489-839 Sentence denotes Electrophoresis in sodium dodecyl sulfate-polyacrylamide of CB peptides (where CB represents cyanogen bromide) from type II collagen of the diseased cartilage showed a doublet band for peptide alpha 1(II)CB10 and evidence for post-translational overmodification of the major peptides (CB8, CB10, and CB11) seen as a retarded electrophoretic mobility.
TextSentencer_T6 840-991 Sentence denotes Peptide CB10 was digested by endoproteinase Asp-N; and on reverse-phase high pressure liquid chromatography, fragments of abnormal mobility were noted.
T6 840-991 Sentence denotes Peptide CB10 was digested by endoproteinase Asp-N; and on reverse-phase high pressure liquid chromatography, fragments of abnormal mobility were noted.
TextSentencer_T7 992-1133 Sentence denotes Sequence analysis of a unique peptide D12 revealed a single amino acid substitution (Gly-->Glu) at position 853 of the triple helical domain.
T7 992-1133 Sentence denotes Sequence analysis of a unique peptide D12 revealed a single amino acid substitution (Gly-->Glu) at position 853 of the triple helical domain.
TextSentencer_T8 1134-1278 Sentence denotes This was confirmed by sequence analysis of amplified COL2A1 cDNA, which revealed a single nucleotide substitution (GGA-->GAA) in 5 of 10 clones.
T8 1134-1278 Sentence denotes This was confirmed by sequence analysis of amplified COL2A1 cDNA, which revealed a single nucleotide substitution (GGA-->GAA) in 5 of 10 clones.
TextSentencer_T9 1279-1498 Sentence denotes Electron micrographs of the diseased cartilage showed a sparse extracellular matrix and chondrocytes containing dilated rough endoplasmic reticulum, which suggested impaired assembly and secretion of the mutant protein.
T9 1279-1498 Sentence denotes Electron micrographs of the diseased cartilage showed a sparse extracellular matrix and chondrocytes containing dilated rough endoplasmic reticulum, which suggested impaired assembly and secretion of the mutant protein.
TextSentencer_T10 1499-1636 Sentence denotes This case further documents the molecular basis of the spondyloepiphyseal dysplasia spectrum of chondrodysplasias as mutations in COL2A1.
T10 1499-1636 Sentence denotes This case further documents the molecular basis of the spondyloepiphyseal dysplasia spectrum of chondrodysplasias as mutations in COL2A1.