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PubMed:1429562 JSONTXT 31 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.
T1 0-112 Sentence denotes The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines.
T2 113-400 Sentence denotes The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region was fused to the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF producing cell lines, the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line.
T2 113-400 Sentence denotes The 1311-base pair human tumor necrosis factor (TNF) alpha promoter region was fused to the luciferase (Luc) reporter gene and studied in a transient transfection system in three TNF producing cell lines, the U937 macrophage cell line, the MLA 144 T cell line, and the 729-6 B cell line.
T3 401-518 Sentence denotes This full length promoter construct can be induced by phorbol 13-myristate acetate (PMA) in each of these cell types.
T3 401-518 Sentence denotes This full length promoter construct can be induced by phorbol 13-myristate acetate (PMA) in each of these cell types.
T4 519-690 Sentence denotes Analysis of a series of 5'-truncations showed several peaks of basal and PMA induced activity suggesting the presence of several positive and negative regulatory elements.
T4 519-690 Sentence denotes Analysis of a series of 5'-truncations showed several peaks of basal and PMA induced activity suggesting the presence of several positive and negative regulatory elements.
T5 691-806 Sentence denotes A PMA responsive element was localized to a region between -95 and -36 bp relative to the transcription start site.
T5 691-806 Sentence denotes A PMA responsive element was localized to a region between -95 and -36 bp relative to the transcription start site.
T6 807-885 Sentence denotes Within this region, single AP-2- and AP-1-like consensus sequences were noted.
T6 807-885 Sentence denotes Within this region, single AP-2- and AP-1-like consensus sequences were noted.
T7 886-960 Sentence denotes These AP-2 and AP-1 sites were each modified with a double point mutation.
T7 886-960 Sentence denotes These AP-2 and AP-1 sites were each modified with a double point mutation.
T8 961-1055 Sentence denotes A modest (20-50%) reduction in TNF promoter activity was observed with the AP-2 site mutation.
T8 961-1055 Sentence denotes A modest (20-50%) reduction in TNF promoter activity was observed with the AP-2 site mutation.
T9 1056-1162 Sentence denotes However, mutation of the AP-1 site markedly diminished both the basal and PMA-activated promoter activity.
T9 1056-1162 Sentence denotes However, mutation of the AP-1 site markedly diminished both the basal and PMA-activated promoter activity.
T10 1163-1320 Sentence denotes Also co-transfections of the wild-type promoter construct with an AP-1/c-jun expression vector resulted in augmented basal and PMA-induced promoter activity.
T10 1163-1320 Sentence denotes Also co-transfections of the wild-type promoter construct with an AP-1/c-jun expression vector resulted in augmented basal and PMA-induced promoter activity.