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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-151 Sentence denotes Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients.
T1 0-151 Sentence denotes Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients.
TextSentencer_T2 152-163 Sentence denotes BACKGROUND:
T2 152-163 Sentence denotes BACKGROUND:
TextSentencer_T3 164-293 Sentence denotes Recent evidence indicates that a subset of axillary node-negative (ANN) breast cancer patients can benefit from adjuvant therapy.
T3 164-293 Sentence denotes Recent evidence indicates that a subset of axillary node-negative (ANN) breast cancer patients can benefit from adjuvant therapy.
TextSentencer_T4 294-434 Sentence denotes Reliable prognostic markers are needed, however, to help clinicians identify these patients and arrive at more rational treatment decisions.
T4 294-434 Sentence denotes Reliable prognostic markers are needed, however, to help clinicians identify these patients and arrive at more rational treatment decisions.
TextSentencer_T5 435-443 Sentence denotes PURPOSE:
T5 435-443 Sentence denotes PURPOSE:
TextSentencer_T6 444-537 Sentence denotes Mutations of the p53 tumor suppressor gene often result in overexpression of the p53 protein.
T6 444-537 Sentence denotes Mutations of the p53 tumor suppressor gene often result in overexpression of the p53 protein.
TextSentencer_T7 538-659 Sentence denotes In this study, we evaluated the prognostic significance of p53 protein overexpression in patients with ANN breast cancer.
T7 538-659 Sentence denotes In this study, we evaluated the prognostic significance of p53 protein overexpression in patients with ANN breast cancer.
TextSentencer_T8 660-844 Sentence denotes We also studied the association between the tumor cell proliferation rate and overexpression of the p53 and c-erbB-2 proteins, both of which have been implicated in cell cycle control.
T8 660-844 Sentence denotes We also studied the association between the tumor cell proliferation rate and overexpression of the p53 and c-erbB-2 proteins, both of which have been implicated in cell cycle control.
TextSentencer_T9 845-899 Sentence denotes The c-erbB-2 protein is the product of the ERBB2 gene.
T9 845-899 Sentence denotes The c-erbB-2 protein is the product of the ERBB2 gene.
TextSentencer_T10 900-908 Sentence denotes METHODS:
T10 900-908 Sentence denotes METHODS:
TextSentencer_T11 909-1085 Sentence denotes Two hundred eighty-nine ANN cases were randomly selected from a population-based cohort of patients who had not received any kind of adjuvant chemotherapy or endocrine therapy.
T11 909-1085 Sentence denotes Two hundred eighty-nine ANN cases were randomly selected from a population-based cohort of patients who had not received any kind of adjuvant chemotherapy or endocrine therapy.
TextSentencer_T12 1086-1291 Sentence denotes Overexpression of the p53 and c-erbB-2 proteins was studied immunohistochemically in archival paraffin-embedded tumor samples, using the CM-1 polyclonal and the TAb 250 monoclonal antibodies, respectively.
T12 1086-1291 Sentence denotes Overexpression of the p53 and c-erbB-2 proteins was studied immunohistochemically in archival paraffin-embedded tumor samples, using the CM-1 polyclonal and the TAb 250 monoclonal antibodies, respectively.
TextSentencer_T13 1292-1385 Sentence denotes The tumor cell proliferation rate was measured as the S-phase fraction by DNA flow cytometry.
T13 1292-1385 Sentence denotes The tumor cell proliferation rate was measured as the S-phase fraction by DNA flow cytometry.
TextSentencer_T14 1386-1442 Sentence denotes Statistical analyses were performed using BMDP software.
T14 1386-1442 Sentence denotes Statistical analyses were performed using BMDP software.
TextSentencer_T15 1443-1451 Sentence denotes RESULTS:
T15 1443-1451 Sentence denotes RESULTS:
TextSentencer_T16 1452-1697 Sentence denotes High-level p53 protein overexpression, found in 41 of the 289 tumors, was most common in tumors with high histologic grade, negative estrogen receptor status, c-erbB-2 protein overexpression, DNA index greater than 1.3, or high S-phase fraction.
T16 1452-1697 Sentence denotes High-level p53 protein overexpression, found in 41 of the 289 tumors, was most common in tumors with high histologic grade, negative estrogen receptor status, c-erbB-2 protein overexpression, DNA index greater than 1.3, or high S-phase fraction.
TextSentencer_T17 1698-1898 Sentence denotes The lowest S-phase levels were found in tumors with neither p53 nor c-erbB-2 protein overexpression; the highest levels were seen in tumors showing overexpression of both proteins (P less than .0001).
T17 1698-1898 Sentence denotes The lowest S-phase levels were found in tumors with neither p53 nor c-erbB-2 protein overexpression; the highest levels were seen in tumors showing overexpression of both proteins (P less than .0001).
TextSentencer_T18 1899-2018 Sentence denotes Both p53 and c-erbB-2 overexpression, as well as tumor size, had independent prognostic value in multivariate analysis.
T18 1899-2018 Sentence denotes Both p53 and c-erbB-2 overexpression, as well as tumor size, had independent prognostic value in multivariate analysis.
TextSentencer_T19 2019-2184 Sentence denotes Eight-year survival of patients with p53 protein overexpression was 56% compared with 81% in patients with no overexpression (relative risk, 3.7; P less than .0001).
T19 2019-2184 Sentence denotes Eight-year survival of patients with p53 protein overexpression was 56% compared with 81% in patients with no overexpression (relative risk, 3.7; P less than .0001).
TextSentencer_T20 2185-2352 Sentence denotes If the S-phase fraction was included in a Cox regression analysis, however, only the tumor size and the S-phase fraction emerged as independent predictors of survival.
T20 2185-2352 Sentence denotes If the S-phase fraction was included in a Cox regression analysis, however, only the tumor size and the S-phase fraction emerged as independent predictors of survival.
TextSentencer_T21 2353-2365 Sentence denotes CONCLUSIONS:
T21 2353-2365 Sentence denotes CONCLUSIONS:
TextSentencer_T22 2366-2562 Sentence denotes Overexpression of the p53 and c-erbB-2 proteins indicates a high malignant potential in ANN breast cancer, but it is not a significant prognostic factor independent of the cell proliferation rate.
T22 2366-2562 Sentence denotes Overexpression of the p53 and c-erbB-2 proteins indicates a high malignant potential in ANN breast cancer, but it is not a significant prognostic factor independent of the cell proliferation rate.
TextSentencer_T23 2563-2734 Sentence denotes The correlation between overexpression of these proteins and an increased S-phase fraction suggests that they may confer a proliferative advantage to cancer cells in vivo.
T23 2563-2734 Sentence denotes The correlation between overexpression of these proteins and an increased S-phase fraction suggests that they may confer a proliferative advantage to cancer cells in vivo.