> top > projects > sentences > docs > PubMed:12975615 > annotations
sentences Home  

PubMed:12975615 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-67 Sentence denotes Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
T1 0-67 Sentence denotes Heparan sulfate 2-O-sulfotransferase (Hs2st) and mouse development.
TextSentencer_T2 68-372 Sentence denotes Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.
T2 68-372 Sentence denotes Heparan sulphate 2-O-sulphotransferase (Hs2st) acts at an intermediate stage in the pathway of biosynthesis of heparan sulphate (HS), catalysing the transfer of sulphate from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to the C2-position of selected hexuronic acid residues within the maturing HS chain.
TextSentencer_T3 373-556 Sentence denotes It is well established that 2-O-sulphation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions.
T3 373-556 Sentence denotes It is well established that 2-O-sulphation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions.
TextSentencer_T4 557-695 Sentence denotes HS plays a central role in embryonic development and cellular function, modulating the activities of an extensive range of growth factors.
T4 557-695 Sentence denotes HS plays a central role in embryonic development and cellular function, modulating the activities of an extensive range of growth factors.
TextSentencer_T5 696-879 Sentence denotes Interestingly, in contrast to the early failure of embryos entirely lacking HS, Hs2st(-/-) mice survive until birth, but die perinatally due to a complete failure of kidney formation.
T5 696-879 Sentence denotes Interestingly, in contrast to the early failure of embryos entirely lacking HS, Hs2st(-/-) mice survive until birth, but die perinatally due to a complete failure of kidney formation.
TextSentencer_T6 880-1023 Sentence denotes The phenotype of Hs2st(-/-) mutant kidneys suggests that signalling between two tissues, ureteric bud and metanephric mesenchyme, is disrupted.
T6 880-1023 Sentence denotes The phenotype of Hs2st(-/-) mutant kidneys suggests that signalling between two tissues, ureteric bud and metanephric mesenchyme, is disrupted.
TextSentencer_T7 1024-1100 Sentence denotes We discuss candidate signalling molecules that may mediate this interaction.
T7 1024-1100 Sentence denotes We discuss candidate signalling molecules that may mediate this interaction.
TextSentencer_T8 1101-1274 Sentence denotes The HS generated by these mice lacks 2-O-sulphate groups but is extensively modified above wild type levels by O-sulphation at C-6 of glucosamine-N-sulfate (GlcNS) residues.
T8 1101-1274 Sentence denotes The HS generated by these mice lacks 2-O-sulphate groups but is extensively modified above wild type levels by O-sulphation at C-6 of glucosamine-N-sulfate (GlcNS) residues.
TextSentencer_T9 1275-1368 Sentence denotes We will discuss the potentially altered role of this atypical HS in growth factor signalling.
T9 1275-1368 Sentence denotes We will discuss the potentially altered role of this atypical HS in growth factor signalling.