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PubMed:12933807 JSONTXT 36 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-97 Sentence denotes Keratocyte phenotype mediates proteoglycan structure: a role for fibroblasts in corneal fibrosis.
T2 98-297 Sentence denotes In pathological corneas, accumulation of fibrotic extracellular matrix is characterized by proteoglycans with altered glycosaminoglycans that contribute to the reduced transparency of scarred tissue.
T3 298-409 Sentence denotes During wound healing, keratocytes in the corneal stroma transdifferentiate into fibroblasts and myofibroblasts.
T4 410-650 Sentence denotes In this study, molecular markers were developed to identify keratocyte, fibroblast, and myofibroblast phenotypes in primary cultures of corneal stromal cells and the structure of glycosaminoglycans secreted by these cells was characterized.
T5 651-835 Sentence denotes Quiescent primary keratocytes expressed abundant protein and mRNA for keratocan and aldehyde dehydrogenase class 3 and secreted proteoglycans containing macromolecular keratan sulfate.
T6 836-1103 Sentence denotes Expression of these marker compounds was reduced in fibroblasts and also in transforming growth factor-beta-induced myofibroblasts, which expressed high levels of alpha-smooth muscle actin, biglycan, and the extra domain A (EDA or EIIIA) form of cellular fibronectin.
T7 1104-1191 Sentence denotes Collagen types I and III mRNAs were elevated in both fibroblasts and in myofibroblasts.
T8 1192-1300 Sentence denotes Expression of these molecular markers clearly distinguishes the phenotypic states of stromal cells in vitro.
T9 1301-1432 Sentence denotes Glycosaminoglycans secreted by fibroblasts and myofibroblasts were qualitatively similar to and differed from those of keratocytes.
T10 1433-1569 Sentence denotes Chondroitin/dermatan sulfate abundance, chain length, and sulfation were increased as keratocytes became fibroblasts and myofibroblasts.
T11 1570-1709 Sentence denotes Fluorophore-assisted carbohydrate electrophoresis analysis demonstrated increased N-acetylgalactosamine sulfation at both 4- and 6-carbons.
T12 1710-1792 Sentence denotes Hyaluronan, absent in keratocytes, was secreted by fibroblasts and myofibroblasts.
T13 1793-1917 Sentence denotes Keratan sulfate biosynthesis, chain length, and sulfation were significantly reduced in both fibroblasts and myofibroblasts.
T14 1918-2123 Sentence denotes The qualitatively similar expression of glycosaminoglycans shared by fibroblasts and myofibroblasts suggests a role for fibroblasts in deposition of non-transparent fibrotic tissue in pathological corneas.