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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-78 Sentence denotes Galectin-8 modulates neutrophil function via interaction with integrin alphaM.
T1 0-78 Sentence denotes Galectin-8 modulates neutrophil function via interaction with integrin alphaM.
TextSentencer_T2 79-185 Sentence denotes The members of the galectin family are associated with diverse cellular events, including immune response.
T2 79-185 Sentence denotes The members of the galectin family are associated with diverse cellular events, including immune response.
TextSentencer_T3 186-251 Sentence denotes We investigated the effects of galectin-8 on neutrophil function.
T3 186-251 Sentence denotes We investigated the effects of galectin-8 on neutrophil function.
TextSentencer_T4 252-409 Sentence denotes Human galectin-8 induced firm and reversible adhesion of peripheral blood neutrophils but not eosinophils to a plastic surface in a lactose-sensitive manner.
T4 252-409 Sentence denotes Human galectin-8 induced firm and reversible adhesion of peripheral blood neutrophils but not eosinophils to a plastic surface in a lactose-sensitive manner.
TextSentencer_T5 410-514 Sentence denotes Other human galectins, galectins-1, -3, and -9, showed low or negligible effects on neutrophil adhesion.
T5 410-514 Sentence denotes Other human galectins, galectins-1, -3, and -9, showed low or negligible effects on neutrophil adhesion.
TextSentencer_T6 515-597 Sentence denotes Confocal microscopy revealed actin bundle formation in the presence of galectin-8.
T6 515-597 Sentence denotes Confocal microscopy revealed actin bundle formation in the presence of galectin-8.
TextSentencer_T7 598-682 Sentence denotes Cytochalasins inhibited both actin assembly and cell adhesion induced by galectin-8.
T7 598-682 Sentence denotes Cytochalasins inhibited both actin assembly and cell adhesion induced by galectin-8.
TextSentencer_T8 683-960 Sentence denotes Affinity purification of galectin-interacting proteins from solubilized neutrophil membrane revealed that N-terminal carbohydrate recognition domain (CRD) of galectin-8 bound promatrix metalloproteinase-9 (proMMP-9), and C-terminal CRD bound integrin alphaM/CD11b and proMMP-9.
T8 683-960 Sentence denotes Affinity purification of galectin-interacting proteins from solubilized neutrophil membrane revealed that N-terminal carbohydrate recognition domain (CRD) of galectin-8 bound promatrix metalloproteinase-9 (proMMP-9), and C-terminal CRD bound integrin alphaM/CD11b and proMMP-9.
TextSentencer_T9 961-1171 Sentence denotes A mutant galectin-8 lacking the carbohydrate-binding activity of N-terminal CRD (galectin-8R69H) retained adhesion-inducing activity, but inactivation of C-terminal CRD (galectin-8R233H) abolished the activity.
T9 961-1171 Sentence denotes A mutant galectin-8 lacking the carbohydrate-binding activity of N-terminal CRD (galectin-8R69H) retained adhesion-inducing activity, but inactivation of C-terminal CRD (galectin-8R233H) abolished the activity.
TextSentencer_T10 1172-1282 Sentence denotes MMP-3-mediated processing of proMMP-9 was accelerated by galectin-8, and this effect was inhibited by lactose.
T10 1172-1282 Sentence denotes MMP-3-mediated processing of proMMP-9 was accelerated by galectin-8, and this effect was inhibited by lactose.
TextSentencer_T11 1283-1332 Sentence denotes Galectins-1 and -3 did not affect the processing.
T11 1283-1332 Sentence denotes Galectins-1 and -3 did not affect the processing.
TextSentencer_T12 1333-1493 Sentence denotes Superoxide production, an essential event in bactericidal function of neutrophils, was stimulated by galectin-8 to an extent comparable to that induced by fMLP.
T12 1333-1493 Sentence denotes Superoxide production, an essential event in bactericidal function of neutrophils, was stimulated by galectin-8 to an extent comparable to that induced by fMLP.
TextSentencer_T13 1494-1571 Sentence denotes Galectin-8R69H but not galectin-8R233H could stimulate superoxide production.
T13 1494-1571 Sentence denotes Galectin-8R69H but not galectin-8R233H could stimulate superoxide production.
TextSentencer_T14 1572-1743 Sentence denotes Taken together, these results suggest that galectin-8 is a novel factor that modulates the neutrophil function related to transendothelial migration and microbial killing.
T14 1572-1743 Sentence denotes Taken together, these results suggest that galectin-8 is a novel factor that modulates the neutrophil function related to transendothelial migration and microbial killing.